Neurotoxicity associated with colistin methanesulfonate treatment is enhanced by concomitant sevoflurane inhalation

Neurotoxicity associated with colistin methanesulfonate treatment is enhanced by concomitant sevoflurane inhalation

Colistin methanesulfonate (CMS) is a cyclic polypeptide antibiotic with neurotoxic side effects. Sevoflurane (Sevo), an inhaled anesthetic, is known to enhance the non-depolarizing effect of neuromuscular relaxants; however, its mechanism of action is unclear. In this study, we investigated the augm...

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Bibliographic Details
Main Authors: Mai Gotoda, Yuki Enoki, Shino Shishido, Kazuaki Taguchi, Kazuaki Matsumoto
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Colistin methanesulfonate
Colistin
Neurotoxicity
Sevoflurane
Ganglionic blocking
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022001342

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