Beneficial insights into postbiotics against colorectal cancer
Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CR...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1111872/full |
| _version_ | 1811155577121800192 |
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| author | Dingka Song Xiuli Wang Yongjing Ma Ning-Ning Liu Hui Wang |
| author_facet | Dingka Song Xiuli Wang Yongjing Ma Ning-Ning Liu Hui Wang |
| author_sort | Dingka Song |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CRC development. Recently, the beneficial role of postbiotics, a new concept in describing microorganism derived substances, in CRC has been uncovered by various studies. However, a comprehensive characterization of the molecular identity, mechanism of action, or routes of administration of postbiotics, particularly their role in CRC, is still lacking. In this review, we outline the current state of research toward the beneficial effects of gut microbiota derived postbiotics against CRC, which will represent the key elements of future precision-medicine approaches in the development of novel therapeutic strategies targeting gut microbiota to improve treatment outcomes in CRC. |
| first_indexed | 2024-04-10T04:35:37Z |
| format | Article |
| id | doaj.art-d6de957e72924b98a8418b6279589902 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T04:35:37Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-d6de957e72924b98a8418b62795899022023-03-10T04:27:24ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11118721111872Beneficial insights into postbiotics against colorectal cancerDingka SongXiuli WangYongjing MaNing-Ning LiuHui WangColorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CRC development. Recently, the beneficial role of postbiotics, a new concept in describing microorganism derived substances, in CRC has been uncovered by various studies. However, a comprehensive characterization of the molecular identity, mechanism of action, or routes of administration of postbiotics, particularly their role in CRC, is still lacking. In this review, we outline the current state of research toward the beneficial effects of gut microbiota derived postbiotics against CRC, which will represent the key elements of future precision-medicine approaches in the development of novel therapeutic strategies targeting gut microbiota to improve treatment outcomes in CRC.https://www.frontiersin.org/articles/10.3389/fnut.2023.1111872/fullpostbioticsCRCgut microbiotanutritional interventionimmune regulation |
| spellingShingle | Dingka Song Xiuli Wang Yongjing Ma Ning-Ning Liu Hui Wang Beneficial insights into postbiotics against colorectal cancer Frontiers in Nutrition postbiotics CRC gut microbiota nutritional intervention immune regulation |
| title | Beneficial insights into postbiotics against colorectal cancer |
| title_full | Beneficial insights into postbiotics against colorectal cancer |
| title_fullStr | Beneficial insights into postbiotics against colorectal cancer |
| title_full_unstemmed | Beneficial insights into postbiotics against colorectal cancer |
| title_short | Beneficial insights into postbiotics against colorectal cancer |
| title_sort | beneficial insights into postbiotics against colorectal cancer |
| topic | postbiotics CRC gut microbiota nutritional intervention immune regulation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1111872/full |
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