Putting the pH into phosphatidic acid signaling
<p>Abstract</p> <p>The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2011-12-01
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| Series: | BMC Biology |
| Online Access: | http://www.biomedcentral.com/1741-7007/9/85 |
| _version_ | 1828435510280847360 |
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| author | Shin John JH Loewen Christopher JR |
| author_facet | Shin John JH Loewen Christopher JR |
| author_sort | Shin John JH |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.</p> |
| first_indexed | 2024-12-10T19:08:23Z |
| format | Article |
| id | doaj.art-d6deae50265b415e8b59a5963c752d98 |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-12-10T19:08:23Z |
| publishDate | 2011-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-d6deae50265b415e8b59a5963c752d982022-12-22T01:36:49ZengBMCBMC Biology1741-70072011-12-01918510.1186/1741-7007-9-85Putting the pH into phosphatidic acid signalingShin John JHLoewen Christopher JR<p>Abstract</p> <p>The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.</p>http://www.biomedcentral.com/1741-7007/9/85 |
| spellingShingle | Shin John JH Loewen Christopher JR Putting the pH into phosphatidic acid signaling BMC Biology |
| title | Putting the pH into phosphatidic acid signaling |
| title_full | Putting the pH into phosphatidic acid signaling |
| title_fullStr | Putting the pH into phosphatidic acid signaling |
| title_full_unstemmed | Putting the pH into phosphatidic acid signaling |
| title_short | Putting the pH into phosphatidic acid signaling |
| title_sort | putting the ph into phosphatidic acid signaling |
| url | http://www.biomedcentral.com/1741-7007/9/85 |
| work_keys_str_mv | AT shinjohnjh puttingthephintophosphatidicacidsignaling AT loewenchristopherjr puttingthephintophosphatidicacidsignaling |