Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research has shown its involvement in cancer, ischemic stroke, and diabetes. L...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-01-01
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| Series: | Journal of Innate Immunity |
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| Online Access: | https://beta.karger.com/Article/FullText/535793 |
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| author | Sarah Truthe Tilman E. Klassert Stefan Schmelz Danny Jonigk Wulf Blankenfeldt Hortense Slevogt |
| author_facet | Sarah Truthe Tilman E. Klassert Stefan Schmelz Danny Jonigk Wulf Blankenfeldt Hortense Slevogt |
| author_sort | Sarah Truthe |
| collection | DOAJ |
| description | Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research has shown its involvement in cancer, ischemic stroke, and diabetes. LOX-1 is a C-type lectin receptor and is involved in the activation of immune cells and inflammatory processes. It may further interact with pathogens, suggesting a role in infections or the host’s response. Summary: This review compiles the current knowledge of potential implications of LOX-1 in inflammatory processes and in host-pathogen interactions with a particular emphasis on its regulatory role in immune responses. Also discussed are genomic and structural variations found in LOX-1 homologs across different species as well as potential involvements of LOX-1 in inflammatory processes from the angle of different cell types and organ-specific interactions. Key Messages: The results presented reveal both similar and different structures in human and murine LOX-1 and provide clues as to the possible origins of different modes of interaction. These descriptions raise concerns about the suitability, particularly of mouse models, that are often used in the analysis of its functionality in humans. Further research should also aim to better understand the mostly unknown binding and interaction mechanisms between LOX-1 and different pathogens. This pursuit will not only enhance our understanding of LOX-1 involvement in inflammatory processes but also identify potential targets for immunomodulatory approaches. |
| first_indexed | 2024-03-08T00:46:32Z |
| format | Article |
| id | doaj.art-d6ded191b0eb439486d19cea53a61c52 |
| institution | Directory Open Access Journal |
| issn | 1662-8128 |
| language | English |
| last_indexed | 2024-03-08T00:46:32Z |
| publishDate | 2024-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Journal of Innate Immunity |
| spelling | doaj.art-d6ded191b0eb439486d19cea53a61c522024-02-15T07:38:01ZengKarger PublishersJournal of Innate Immunity1662-81282024-01-0116110513210.1159/000535793535793Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated InteractionsSarah Truthe0Tilman E. Klassert1Stefan Schmelz2Danny Jonigk3Wulf Blankenfeldt4Hortense Slevogt5Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, German Center for Lung Research (DZL), BREATH, Hannover, GermanyDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, German Center for Lung Research (DZL), BREATH, Hannover, GermanyDepartment Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, GermanyInstitute of Pathology, RWTH Medical University Aachen, Aachen, GermanyDepartment Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, German Center for Lung Research (DZL), BREATH, Hannover, GermanyBackground: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research has shown its involvement in cancer, ischemic stroke, and diabetes. LOX-1 is a C-type lectin receptor and is involved in the activation of immune cells and inflammatory processes. It may further interact with pathogens, suggesting a role in infections or the host’s response. Summary: This review compiles the current knowledge of potential implications of LOX-1 in inflammatory processes and in host-pathogen interactions with a particular emphasis on its regulatory role in immune responses. Also discussed are genomic and structural variations found in LOX-1 homologs across different species as well as potential involvements of LOX-1 in inflammatory processes from the angle of different cell types and organ-specific interactions. Key Messages: The results presented reveal both similar and different structures in human and murine LOX-1 and provide clues as to the possible origins of different modes of interaction. These descriptions raise concerns about the suitability, particularly of mouse models, that are often used in the analysis of its functionality in humans. Further research should also aim to better understand the mostly unknown binding and interaction mechanisms between LOX-1 and different pathogens. This pursuit will not only enhance our understanding of LOX-1 involvement in inflammatory processes but also identify potential targets for immunomodulatory approaches.https://beta.karger.com/Article/FullText/535793c-type lectin-like receptorsinfection responseinflammationlectin-like oxidized low-density lipoprotein receptor-1lox-1oxidized low-density lipoprotein |
| spellingShingle | Sarah Truthe Tilman E. Klassert Stefan Schmelz Danny Jonigk Wulf Blankenfeldt Hortense Slevogt Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions Journal of Innate Immunity c-type lectin-like receptors infection response inflammation lectin-like oxidized low-density lipoprotein receptor-1 lox-1 oxidized low-density lipoprotein |
| title | Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions |
| title_full | Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions |
| title_fullStr | Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions |
| title_full_unstemmed | Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions |
| title_short | Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions |
| title_sort | role of lectin like oxidized low density lipoprotein receptor 1 in inflammation and pathogen associated interactions |
| topic | c-type lectin-like receptors infection response inflammation lectin-like oxidized low-density lipoprotein receptor-1 lox-1 oxidized low-density lipoprotein |
| url | https://beta.karger.com/Article/FullText/535793 |
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