Koronary heart disease clinical course, post-infarction remodeling, psychological status, and hospitalization time in patients with various ACE genotypes
Clinical, instrumental and psychosomatic associations of ACE gene insertion/deletion (I/D) polymorphism were studied in inpatients with coronary heart disease (CHD): unstable angina (UA) - 32, myocardial infarction (MI) - 80. The control group included 66 healthy volunteers (CG). ACE gene D allele w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2006-06-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1830 |
| Summary: | Clinical, instrumental and psychosomatic associations of ACE gene insertion/deletion (I/D) polymorphism were studied in inpatients with coronary heart disease (CHD): unstable angina (UA) - 32, myocardial infarction (MI) - 80. The control group included 66 healthy volunteers (CG). ACE gene D allele was more prevalent than I allele (p < 0.02) in CHD and MI patients. These groups also had significant difference in DD genotype prevalence, comparing to CG (p < 0.05). According to echocardiography results, severe left ventricular hypertrophy (IVH) was associated with DD genotype. According to psychometry data, patients with DD genotype had increased levels of total hostility and Type A behavior manifestation than patients with ID or II genotype (p < 0.05). Prolonged hospitalization time in MI patients with DD genotype was significantly associated with severity of Type A behavior and various hostility components (p < 0.05). |
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| ISSN: | 1560-4071 2618-7620 |