MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation
Implantation in humans is a multistep process that involves apposition, adhesion, and invasion of the developing blastocyst into the receptive maternal endometrium. Though significant volume of research in this direction has identified important players orchestrating this delicate process, there are...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-10-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/26/4/10.2741/4915 |
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| author | Ruby Dhar Sunil Singh Indrani Mukherjee Karthikeyan Pethusamy Kakali Purkayastha Prasenjit Das Jai Bhagwan Sharma Radhey Shyam Sharma Subhradip Karmakar |
| author_facet | Ruby Dhar Sunil Singh Indrani Mukherjee Karthikeyan Pethusamy Kakali Purkayastha Prasenjit Das Jai Bhagwan Sharma Radhey Shyam Sharma Subhradip Karmakar |
| author_sort | Ruby Dhar |
| collection | DOAJ |
| description | Implantation in humans is a multistep process that involves apposition, adhesion, and invasion of the developing blastocyst into the receptive maternal endometrium. Though significant volume of research in this direction has identified important players orchestrating this delicate process, there are still gaps in our understanding of all the sequence of events during embryo implantation. Also, the early pregnancy-related complications that lead to fetal loss and miscarriage often occur in this critical window of implantation, which is primarily defined as the time when the maternal endometrium is supposed to be most receptive to the free blastocyst that emerges out from the zona pellucida. Studies in humans and rodents have identified several mediators like folliculin, LIF, IL11Rα, splicing factor SC35, etc. to be essential for early implantation. Trophoblasts, that form the outer epithelial layer of the blastocyst, participate in the formation of the placenta. During placentation, invasive extravillous trophoblasts (EVTs), migrate into the endometrium, and a transient epithelial to mesenchymal transition (EMT) and remodel the uterine arteries for blood and nutrient exchange. |
| first_indexed | 2024-12-18T10:43:00Z |
| format | Article |
| id | doaj.art-d6df5c0b3e7b4b12ab65d93876d0ddd9 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-18T10:43:00Z |
| publishDate | 2020-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-d6df5c0b3e7b4b12ab65d93876d0ddd92022-12-21T21:10:36ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-10-0126471774310.2741/4915S2768-6701(21)00116-7MTiness in pseudo-malignant behavior of trophoblasts during embryo implantationRuby Dhar0Sunil Singh1Indrani Mukherjee2Karthikeyan Pethusamy3Kakali Purkayastha4Prasenjit Das5Jai Bhagwan Sharma6Radhey Shyam Sharma7Subhradip Karmakar8Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaICMR Headquaters, New Delhi, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, IndiaImplantation in humans is a multistep process that involves apposition, adhesion, and invasion of the developing blastocyst into the receptive maternal endometrium. Though significant volume of research in this direction has identified important players orchestrating this delicate process, there are still gaps in our understanding of all the sequence of events during embryo implantation. Also, the early pregnancy-related complications that lead to fetal loss and miscarriage often occur in this critical window of implantation, which is primarily defined as the time when the maternal endometrium is supposed to be most receptive to the free blastocyst that emerges out from the zona pellucida. Studies in humans and rodents have identified several mediators like folliculin, LIF, IL11Rα, splicing factor SC35, etc. to be essential for early implantation. Trophoblasts, that form the outer epithelial layer of the blastocyst, participate in the formation of the placenta. During placentation, invasive extravillous trophoblasts (EVTs), migrate into the endometrium, and a transient epithelial to mesenchymal transition (EMT) and remodel the uterine arteries for blood and nutrient exchange.https://www.imrpress.com/journal/FBL/26/4/10.2741/4915trophoblast invasionemtpseudomalignantproteasesfeto-maternal interfacereview |
| spellingShingle | Ruby Dhar Sunil Singh Indrani Mukherjee Karthikeyan Pethusamy Kakali Purkayastha Prasenjit Das Jai Bhagwan Sharma Radhey Shyam Sharma Subhradip Karmakar MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation Frontiers in Bioscience-Landmark trophoblast invasion emt pseudomalignant proteases feto-maternal interface review |
| title | MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation |
| title_full | MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation |
| title_fullStr | MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation |
| title_full_unstemmed | MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation |
| title_short | MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation |
| title_sort | mtiness in pseudo malignant behavior of trophoblasts during embryo implantation |
| topic | trophoblast invasion emt pseudomalignant proteases feto-maternal interface review |
| url | https://www.imrpress.com/journal/FBL/26/4/10.2741/4915 |
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