Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease
Renal hypoxia has recently been implicated as a key contributor and indicator of various glomerular diseases. As such, monitoring changes in renal oxygenation in these disorders may provide an early diagnostic advantage that could prevent potential adverse outcomes. Blood oxygen level-dependent magn...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Transplantology |
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| Online Access: | https://www.mdpi.com/2673-3943/2/2/11 |
| _version_ | 1827696095001575424 |
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| author | Daniel R. Nemirovsky Puneet Gupta Sophia Hu Raymond Wong Avnesh S. Thakor |
| author_facet | Daniel R. Nemirovsky Puneet Gupta Sophia Hu Raymond Wong Avnesh S. Thakor |
| author_sort | Daniel R. Nemirovsky |
| collection | DOAJ |
| description | Renal hypoxia has recently been implicated as a key contributor and indicator of various glomerular diseases. As such, monitoring changes in renal oxygenation in these disorders may provide an early diagnostic advantage that could prevent potential adverse outcomes. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) is an emerging noninvasive technique for assessing renal oxygenation in glomerular disease. Although BOLD MRI has produced promising initial results for the use in certain renal pathologies, the use of BOLD imaging in glomerular diseases, including primary and secondary nephrotic and nephritic syndromes, is relatively unexplored. Early BOLD studies on primary nephrotic syndrome, nephrotic syndrome secondary to diabetes mellitus, and nephritic syndrome secondary to systemic lupus erythematosus have shown promising results to support its future clinical utility. In this review, we outline the advancements made in understanding the use of BOLD MRI for the assessment, diagnosis, and screening of these pathologies. |
| first_indexed | 2024-03-10T12:40:59Z |
| format | Article |
| id | doaj.art-d6e0b20280134317a54fa5613467ce41 |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-10T12:40:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-d6e0b20280134317a54fa5613467ce412023-11-21T13:56:19ZengMDPI AGTransplantology2673-39432021-04-012210911710.3390/transplantology2020011Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular DiseaseDaniel R. Nemirovsky0Puneet Gupta1Sophia Hu2Raymond Wong3Avnesh S. Thakor4School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USASchool of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USAPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Cell and Molecular Biology, University of South Florida, Tampa, FL 33620, USAInterventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA 94305, USARenal hypoxia has recently been implicated as a key contributor and indicator of various glomerular diseases. As such, monitoring changes in renal oxygenation in these disorders may provide an early diagnostic advantage that could prevent potential adverse outcomes. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) is an emerging noninvasive technique for assessing renal oxygenation in glomerular disease. Although BOLD MRI has produced promising initial results for the use in certain renal pathologies, the use of BOLD imaging in glomerular diseases, including primary and secondary nephrotic and nephritic syndromes, is relatively unexplored. Early BOLD studies on primary nephrotic syndrome, nephrotic syndrome secondary to diabetes mellitus, and nephritic syndrome secondary to systemic lupus erythematosus have shown promising results to support its future clinical utility. In this review, we outline the advancements made in understanding the use of BOLD MRI for the assessment, diagnosis, and screening of these pathologies.https://www.mdpi.com/2673-3943/2/2/11BOLD MRIglomerularhypoxianephroticnephritic |
| spellingShingle | Daniel R. Nemirovsky Puneet Gupta Sophia Hu Raymond Wong Avnesh S. Thakor Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease Transplantology BOLD MRI glomerular hypoxia nephrotic nephritic |
| title | Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease |
| title_full | Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease |
| title_fullStr | Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease |
| title_full_unstemmed | Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease |
| title_short | Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease |
| title_sort | blood oxygen level dependent bold mri in glomerular disease |
| topic | BOLD MRI glomerular hypoxia nephrotic nephritic |
| url | https://www.mdpi.com/2673-3943/2/2/11 |
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