Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients
The relationship between motor unit (MU) firing behavior and the severity of neurodegeneration in Parkinson’s disease (PD) is not clear. This study aimed to elucidate the association between degeneration with dopaminergic pathways and MU firing behavior in people with PD. Fourteen females with PD (a...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Online Access: | https://www.mdpi.com/1424-8220/21/19/6615 |
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| author | Yuichi Nishikawa Kohei Watanabe Aleš Holobar Tetsuya Takahashi Noriaki Maeda Hirofumi Maruyama Shinobu Tanaka Allison S Hyngstrom |
| author_facet | Yuichi Nishikawa Kohei Watanabe Aleš Holobar Tetsuya Takahashi Noriaki Maeda Hirofumi Maruyama Shinobu Tanaka Allison S Hyngstrom |
| author_sort | Yuichi Nishikawa |
| collection | DOAJ |
| description | The relationship between motor unit (MU) firing behavior and the severity of neurodegeneration in Parkinson’s disease (PD) is not clear. This study aimed to elucidate the association between degeneration with dopaminergic pathways and MU firing behavior in people with PD. Fourteen females with PD (age, 72.6 ± 7.2 years, disease duration, 3.5 ± 2.1 years) were enrolled in this study. All participants performed a submaximal, isometric knee extension ramp-up contraction from 0% to 80% of their maximal voluntary contraction strength. We used high-density surface electromyography with 64 electrodes to record the muscle activity of the vastus lateralis muscle and decomposed the signals with the convolution kernel compensation technique to extract the signals of individual MUs. We calculated the degree of degeneration of the central lesion-specific binding ratio by dopamine transporter single-photon emission computed tomography. The primary, novel results were as follows: (1) moderate-to-strong correlations were observed between the degree of degeneration of the central lesion and MU firing behavior; (2) a moderate correlation was observed between clinical measures of disease severity and MU firing behavior; and (3) the methods of predicting central nervous system degeneration from MU firing behavior abnormalities had a high detection accuracy with an area under the curve >0.83. These findings suggest that abnormalities in MU activity can be used to predict central nervous system degeneration following PD. |
| first_indexed | 2024-03-10T06:51:33Z |
| format | Article |
| id | doaj.art-d6e2c9f5c9e544cb9e3e4fde0c68e77d |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T06:51:33Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-d6e2c9f5c9e544cb9e3e4fde0c68e77d2023-11-22T16:48:47ZengMDPI AGSensors1424-82202021-10-012119661510.3390/s21196615Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease PatientsYuichi Nishikawa0Kohei Watanabe1Aleš Holobar2Tetsuya Takahashi3Noriaki Maeda4Hirofumi Maruyama5Shinobu Tanaka6Allison S Hyngstrom7Faculty of Frontier Engineering, Institute of Science & Engineering, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota 470-0393, JapanFaculty of Electrical Engineering and Computer Science, University of Maribor, 2000 Maribor, SloveniaDepartment of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, Higashihiroshima 739-2695, JapanDivision of Sports Rehabilitation, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanFaculty of Frontier Engineering, Institute of Science & Engineering, Kanazawa University, Kanazawa 920-1192, JapanDepartment of Physical Therapy, Marquette University, Milwaukee, WI 53201, USAThe relationship between motor unit (MU) firing behavior and the severity of neurodegeneration in Parkinson’s disease (PD) is not clear. This study aimed to elucidate the association between degeneration with dopaminergic pathways and MU firing behavior in people with PD. Fourteen females with PD (age, 72.6 ± 7.2 years, disease duration, 3.5 ± 2.1 years) were enrolled in this study. All participants performed a submaximal, isometric knee extension ramp-up contraction from 0% to 80% of their maximal voluntary contraction strength. We used high-density surface electromyography with 64 electrodes to record the muscle activity of the vastus lateralis muscle and decomposed the signals with the convolution kernel compensation technique to extract the signals of individual MUs. We calculated the degree of degeneration of the central lesion-specific binding ratio by dopamine transporter single-photon emission computed tomography. The primary, novel results were as follows: (1) moderate-to-strong correlations were observed between the degree of degeneration of the central lesion and MU firing behavior; (2) a moderate correlation was observed between clinical measures of disease severity and MU firing behavior; and (3) the methods of predicting central nervous system degeneration from MU firing behavior abnormalities had a high detection accuracy with an area under the curve >0.83. These findings suggest that abnormalities in MU activity can be used to predict central nervous system degeneration following PD.https://www.mdpi.com/1424-8220/21/19/6615EMG recordingParkinson’s diseasemotor unit recruitmentdopamine receptor |
| spellingShingle | Yuichi Nishikawa Kohei Watanabe Aleš Holobar Tetsuya Takahashi Noriaki Maeda Hirofumi Maruyama Shinobu Tanaka Allison S Hyngstrom Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients Sensors EMG recording Parkinson’s disease motor unit recruitment dopamine receptor |
| title | Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients |
| title_full | Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients |
| title_fullStr | Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients |
| title_full_unstemmed | Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients |
| title_short | Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients |
| title_sort | association between the degree of pre synaptic dopaminergic pathway degeneration and motor unit firing behavior in parkinson s disease patients |
| topic | EMG recording Parkinson’s disease motor unit recruitment dopamine receptor |
| url | https://www.mdpi.com/1424-8220/21/19/6615 |
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