Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is heterogeneous in etiology, phenotype and biology. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumors and have become a standard “Avatar” model for human cancer research. However, res...

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Main Authors: Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss, Claudia Maletzki
格式: 文件
语言:English
出版: BMC 2021-08-01
丛编:Journal of Experimental & Clinical Cancer Research
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在线阅读:https://doi.org/10.1186/s13046-021-02047-w