Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems
Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/12/980 |
| _version_ | 1797381005726711808 |
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| author | Long Toan Trinh Saebin Lim Hyun Jong Lee Il Tae Kim |
| author_facet | Long Toan Trinh Saebin Lim Hyun Jong Lee Il Tae Kim |
| author_sort | Long Toan Trinh |
| collection | DOAJ |
| description | Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs. |
| first_indexed | 2024-03-08T20:45:08Z |
| format | Article |
| id | doaj.art-d6e4daaf1f4742b0a975cd0061e59bd7 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-08T20:45:08Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d6e4daaf1f4742b0a975cd0061e59bd72023-12-22T14:10:49ZengMDPI AGGels2310-28612023-12-0191298010.3390/gels9120980Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery SystemsLong Toan Trinh0Saebin Lim1Hyun Jong Lee2Il Tae Kim3Department of Chemical and Biological Engineering, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Chemical and Biological Engineering, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Chemical and Biological Engineering, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Chemical and Biological Engineering, Gachon University, Seongnam-si 13120, Republic of KoreaEfficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs.https://www.mdpi.com/2310-2861/9/12/980acetaminophenbioavailabilitydrug deliverypolysuccinimideprolongedsodium alginate |
| spellingShingle | Long Toan Trinh Saebin Lim Hyun Jong Lee Il Tae Kim Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems Gels acetaminophen bioavailability drug delivery polysuccinimide prolonged sodium alginate |
| title | Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems |
| title_full | Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems |
| title_fullStr | Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems |
| title_full_unstemmed | Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems |
| title_short | Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems |
| title_sort | development of efficient sodium alginate polysuccinimide based hydrogels as biodegradable acetaminophen delivery systems |
| topic | acetaminophen bioavailability drug delivery polysuccinimide prolonged sodium alginate |
| url | https://www.mdpi.com/2310-2861/9/12/980 |
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