Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats
This study examines and compares the walking function in contusion and distraction spinal cord injury (SCI) mechanisms. Moderate contusion and distraction SCIs were surgically induced between C5 and C6 in Sprague-Dawley male rats. The CatWalk system was used to perform gait analysis of walkway walki...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-08-01
|
| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519869615 |
| _version_ | 1819018760480096256 |
|---|---|
| author | Yue Guo Hai Hu Jingchao Wang Meiyan Zhang Kinon Chen |
| author_facet | Yue Guo Hai Hu Jingchao Wang Meiyan Zhang Kinon Chen |
| author_sort | Yue Guo |
| collection | DOAJ |
| description | This study examines and compares the walking function in contusion and distraction spinal cord injury (SCI) mechanisms. Moderate contusion and distraction SCIs were surgically induced between C5 and C6 in Sprague-Dawley male rats. The CatWalk system was used to perform gait analysis of walkway walking. The ladder rung walking test was used to quantify skilled locomotor movements of ladder rung walking. It was found that the inter-paw coordination, paw support, front paw kinematics, hind paw kinematics, and skilled movements were significantly different before and after contusion and distraction. Step sequence duration, diagonal support, forelimb intensity, forelimb duty cycle, forelimb paw angle, and forelimb swing speed were more greatly affected in distraction than in contusion at 2 weeks post-injury, whereas hindlimb stand was more greatly affected in contusion than in distraction at 8 weeks post-injury. After 8 weeks post-injury, diagonal coupling—variation, girdle coupling—variation, ipsilateral coupling—mean, forelimb maximum contact at, forelimb intensity, forelimb paw angle, and number of forelimb misplacements recovered to normal in contusion but not in distraction, whereas step sequence duration, ipsilateral coupling—variation, forelimb stand, forelimb duty cycle, hindlimb swing duration, hindlimb swing speed, and number of forelimb slips recovered to normal in distraction but not in contusion. Some of the behavioral outcomes, but not the others, were linearly correlated with the histological outcomes. In conclusion, walking deficits and recovery can be affected by the type of common traumatic SCI. |
| first_indexed | 2024-12-21T03:24:32Z |
| format | Article |
| id | doaj.art-d6e6fcb28b544adb8a5dd105525e4bf0 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-12-21T03:24:32Z |
| publishDate | 2019-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-d6e6fcb28b544adb8a5dd105525e4bf02022-12-21T19:17:39ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952019-08-011310.1177/1179069519869615Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in RatsYue Guo0Hai Hu1Jingchao Wang2Meiyan Zhang3Kinon Chen4Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University (BUAA), Beijing, ChinaBeijing Advanced Innovation Center for Biomedical Engineering, Beihang University (BUAA), Beijing, ChinaBeijing Advanced Innovation Center for Biomedical Engineering, Beihang University (BUAA), Beijing, ChinaBeijing Advanced Innovation Center for Biomedical Engineering, Beihang University (BUAA), Beijing, ChinaInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC), Vancouver, BC, CanadaThis study examines and compares the walking function in contusion and distraction spinal cord injury (SCI) mechanisms. Moderate contusion and distraction SCIs were surgically induced between C5 and C6 in Sprague-Dawley male rats. The CatWalk system was used to perform gait analysis of walkway walking. The ladder rung walking test was used to quantify skilled locomotor movements of ladder rung walking. It was found that the inter-paw coordination, paw support, front paw kinematics, hind paw kinematics, and skilled movements were significantly different before and after contusion and distraction. Step sequence duration, diagonal support, forelimb intensity, forelimb duty cycle, forelimb paw angle, and forelimb swing speed were more greatly affected in distraction than in contusion at 2 weeks post-injury, whereas hindlimb stand was more greatly affected in contusion than in distraction at 8 weeks post-injury. After 8 weeks post-injury, diagonal coupling—variation, girdle coupling—variation, ipsilateral coupling—mean, forelimb maximum contact at, forelimb intensity, forelimb paw angle, and number of forelimb misplacements recovered to normal in contusion but not in distraction, whereas step sequence duration, ipsilateral coupling—variation, forelimb stand, forelimb duty cycle, hindlimb swing duration, hindlimb swing speed, and number of forelimb slips recovered to normal in distraction but not in contusion. Some of the behavioral outcomes, but not the others, were linearly correlated with the histological outcomes. In conclusion, walking deficits and recovery can be affected by the type of common traumatic SCI.https://doi.org/10.1177/1179069519869615 |
| spellingShingle | Yue Guo Hai Hu Jingchao Wang Meiyan Zhang Kinon Chen Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats Journal of Experimental Neuroscience |
| title | Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats |
| title_full | Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats |
| title_fullStr | Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats |
| title_full_unstemmed | Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats |
| title_short | Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats |
| title_sort | walking function after cervical contusion and distraction spinal cord injuries in rats |
| url | https://doi.org/10.1177/1179069519869615 |
| work_keys_str_mv | AT yueguo walkingfunctionaftercervicalcontusionanddistractionspinalcordinjuriesinrats AT haihu walkingfunctionaftercervicalcontusionanddistractionspinalcordinjuriesinrats AT jingchaowang walkingfunctionaftercervicalcontusionanddistractionspinalcordinjuriesinrats AT meiyanzhang walkingfunctionaftercervicalcontusionanddistractionspinalcordinjuriesinrats AT kinonchen walkingfunctionaftercervicalcontusionanddistractionspinalcordinjuriesinrats |