Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia
Objectives: Binocular rivalry is a typical example of bistable perception that arises when two monocular images are simultaneously presented to each eye. Binocular rivalry is a heritable perceptual cognitive function that is impaired in patients with schizophrenia (SZ). Despite its potential suitabi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2018.00634/full |
| _version_ | 1818304797375201280 |
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| author | Guixian Xiao Guixian Xiao Guixian Xiao Kongliang He Xingui Chen Xingui Chen Xingui Chen Lu Wang Lu Wang Lu Wang Xiaomeng Bai Liling Gao Chunyan Zhu Chunyan Zhu Chunyan Zhu Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang |
| author_facet | Guixian Xiao Guixian Xiao Guixian Xiao Kongliang He Xingui Chen Xingui Chen Xingui Chen Lu Wang Lu Wang Lu Wang Xiaomeng Bai Liling Gao Chunyan Zhu Chunyan Zhu Chunyan Zhu Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang |
| author_sort | Guixian Xiao |
| collection | DOAJ |
| description | Objectives: Binocular rivalry is a typical example of bistable perception that arises when two monocular images are simultaneously presented to each eye. Binocular rivalry is a heritable perceptual cognitive function that is impaired in patients with schizophrenia (SZ). Despite its potential suitability as a visual endophenotype, binocular rivalry has hardly been studied in the unaffected siblings of schizophrenia (SIB). There is also little research about whether binocular rivalry is a potential visual endophenotype between SZ and SIB.Methods: In our cross-sectional study, we included 40 SZ and their unaffected SIBs, as well as 40 age- and sex-matched healthy controls (HC). All subjects underwent the binocular rivalry test, the Positive and Negative Syndrome Scale (PANSS) and a battery of cognitive neuropsychological assessments evaluating attention, memory and executive function domains.Results: Our results demonstrate that the switching rate in SZ was significantly slower than in HC (p < 0.001), and compared to the SIB, the mean alternation rates were significantly different (p < 0.01). Moreover, there was a significant difference in mean switching rate between the SIB and the HC (p < 0.001). There was no significant correlation between the alternation rate of binocular rivalry and these cognitive tasks and the PANSS scores.Conclusion: The present study shows that SZ and SIB both exhibit changes in binocular rivalry, with SIB exhibiting intermediate performance compared with that of SZ and the HC. This supports the claim that the switching rate for SZ differs from that of SIB and suggests that binocular rivalry may qualify as a visual endophenotype for SZ. |
| first_indexed | 2024-12-13T06:16:24Z |
| format | Article |
| id | doaj.art-d6e8fb8966ae43a98adb1d256bfc17ec |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T06:16:24Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d6e8fb8966ae43a98adb1d256bfc17ec2022-12-21T23:56:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-09-011210.3389/fnins.2018.00634381085Slow Binocular Rivalry as a Potential Endophenotype of SchizophreniaGuixian Xiao0Guixian Xiao1Guixian Xiao2Kongliang He3Xingui Chen4Xingui Chen5Xingui Chen6Lu Wang7Lu Wang8Lu Wang9Xiaomeng Bai10Liling Gao11Chunyan Zhu12Chunyan Zhu13Chunyan Zhu14Kai Wang15Kai Wang16Kai Wang17Kai Wang18Kai Wang19Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Anhui, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Anhui, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Anhui, ChinaDepartment of Medical Psychology, Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Anhui, ChinaDepartment of Medical Psychology, Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Anhui, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Medical Psychology, Anhui Medical University, Hefei, ChinaObjectives: Binocular rivalry is a typical example of bistable perception that arises when two monocular images are simultaneously presented to each eye. Binocular rivalry is a heritable perceptual cognitive function that is impaired in patients with schizophrenia (SZ). Despite its potential suitability as a visual endophenotype, binocular rivalry has hardly been studied in the unaffected siblings of schizophrenia (SIB). There is also little research about whether binocular rivalry is a potential visual endophenotype between SZ and SIB.Methods: In our cross-sectional study, we included 40 SZ and their unaffected SIBs, as well as 40 age- and sex-matched healthy controls (HC). All subjects underwent the binocular rivalry test, the Positive and Negative Syndrome Scale (PANSS) and a battery of cognitive neuropsychological assessments evaluating attention, memory and executive function domains.Results: Our results demonstrate that the switching rate in SZ was significantly slower than in HC (p < 0.001), and compared to the SIB, the mean alternation rates were significantly different (p < 0.01). Moreover, there was a significant difference in mean switching rate between the SIB and the HC (p < 0.001). There was no significant correlation between the alternation rate of binocular rivalry and these cognitive tasks and the PANSS scores.Conclusion: The present study shows that SZ and SIB both exhibit changes in binocular rivalry, with SIB exhibiting intermediate performance compared with that of SZ and the HC. This supports the claim that the switching rate for SZ differs from that of SIB and suggests that binocular rivalry may qualify as a visual endophenotype for SZ.https://www.frontiersin.org/article/10.3389/fnins.2018.00634/fullbinocular rivalrySchizophreniasiblingvisual endophenotypecognitive function |
| spellingShingle | Guixian Xiao Guixian Xiao Guixian Xiao Kongliang He Xingui Chen Xingui Chen Xingui Chen Lu Wang Lu Wang Lu Wang Xiaomeng Bai Liling Gao Chunyan Zhu Chunyan Zhu Chunyan Zhu Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia Frontiers in Neuroscience binocular rivalry Schizophrenia sibling visual endophenotype cognitive function |
| title | Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia |
| title_full | Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia |
| title_fullStr | Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia |
| title_full_unstemmed | Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia |
| title_short | Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia |
| title_sort | slow binocular rivalry as a potential endophenotype of schizophrenia |
| topic | binocular rivalry Schizophrenia sibling visual endophenotype cognitive function |
| url | https://www.frontiersin.org/article/10.3389/fnins.2018.00634/full |
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