LRPPRC facilitates tumor progression and immune evasion through upregulation of m6A modification of PD-L1 mRNA in hepatocellular carcinoma

LRPPRC facilitates tumor progression and immune evasion through upregulation of m6A modification of PD-L1 mRNA in hepatocellular carcinoma

ObjectiveLRPPRC is a newly discovered N6-methyladenosine (m6A) modification reader, which potentially affects hepatocellular carcinoma (HCC) progression. PD-L1 in tumor cells is essential for tumor immune evasion. This work investigated the LRPPRC-mediated m6A-modification effect on PD-L1 mRNA and i...

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Bibliographic Details
Main Authors:	Houhong Wang, Amao Tang, Yayun Cui, Huihui Gong, Heng Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Immunology
Subjects:	hepatocellular carcinoma LRPPRC PD-L1 immune evasion m6A modification anti-tumor immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1144774/full

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