<b>Electrochemical oxidation of niclosamide at a glassy carbon electrode and its determination by voltammetry</b>
Cyclic voltammetry, square-wave voltammetry and controlled potential electrolysis have been used to study the electrochemical oxidation behaviour of niclosamide at a glassy carbon electrode. The number of electrons transferred, the wave characteristics, the diffusion coefficient and reversibility of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2003-06-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://ajol.info/index.php/bcse/article/view/61740 |
| Summary: | Cyclic voltammetry, square-wave voltammetry and controlled potential electrolysis have been used to study the electrochemical oxidation behaviour of niclosamide at a glassy carbon electrode. The number of electrons transferred, the wave characteristics, the diffusion coefficient and reversibility of the reactions have been investigated. Following optimisation of voltammetric parameters, pH, and reproducibility, a linear calibration curve over the range 1 x 10<sup>-6</sup> – 1 x 10<sup>-4</sup> mol dm<sup>-3</sup> niclosamide was achieved. The detection limit was found to be 8 x 10<sup>-7</sup> mol dm<sup>-3</sup>. For eight successive determinations of 1 x 10<sup>-5</sup> mol dm<sup>-3</sup> niclosamide, a relative standard deviation of 3.6% was obtained. This voltammetric method was applied for the determination of niclosamide in tablets. |
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| ISSN: | 1011-3924 1726-801X |