Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers
Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement...
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| Format: | Article |
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MDPI AG
2018-09-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | http://www.mdpi.com/2079-4983/9/3/52 |
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| author | Ameya Sharma Vivek Puri Vandita Kakkar Inderbir Singh |
| author_facet | Ameya Sharma Vivek Puri Vandita Kakkar Inderbir Singh |
| author_sort | Ameya Sharma |
| collection | DOAJ |
| description | Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers. |
| first_indexed | 2024-04-11T12:33:54Z |
| format | Article |
| id | doaj.art-d6eac0a7ddc246e78544f7acd3434df8 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-11T12:33:54Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-d6eac0a7ddc246e78544f7acd3434df82022-12-22T04:23:41ZengMDPI AGJournal of Functional Biomaterials2079-49832018-09-01935210.3390/jfb9030052jfb9030052Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric UlcersAmeya Sharma0Vivek Puri1Vandita Kakkar2Inderbir Singh3Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala 140401, IndiaDepartment of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala 140401, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160101, IndiaDepartment of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala 140401, IndiaSilymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers.http://www.mdpi.com/2079-4983/9/3/52Microbeadssilymarinchitosanmontmorillonitegastric ulcers |
| spellingShingle | Ameya Sharma Vivek Puri Vandita Kakkar Inderbir Singh Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers Journal of Functional Biomaterials Microbeads silymarin chitosan montmorillonite gastric ulcers |
| title | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
| title_full | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
| title_fullStr | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
| title_full_unstemmed | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
| title_short | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
| title_sort | formulation and evaluation of silymarin loaded chitosan montmorilloite microbeads for the potential treatment of gastric ulcers |
| topic | Microbeads silymarin chitosan montmorillonite gastric ulcers |
| url | http://www.mdpi.com/2079-4983/9/3/52 |
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