Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been do...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-10-01
|
| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917303372 |
| _version_ | 1819098948783046656 |
|---|---|
| author | Zhao Bi Bin Xue |
| author_facet | Zhao Bi Bin Xue |
| author_sort | Zhao Bi |
| collection | DOAJ |
| description | MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been done on miRNA:mRNA interactions. Nonetheless, the interactions from different sources are not always consistent. In this study, we integrated multiple online resources, including mirTarBase, TarBase, miRanda, miRDB, PITA, and TargetScan, and developed eleven large-scale datasets containing miRNA:mRNA interactions that are consistent among a specific subgroup of above-mentioned online resources. In addition, a new integrated confidence score was designed to show the significance for all the miRNA:mRNA interactions. |
| first_indexed | 2024-12-22T00:39:06Z |
| format | Article |
| id | doaj.art-d6eb02b027c94386be98b42454acd0c9 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-22T00:39:06Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-d6eb02b027c94386be98b42454acd0c92022-12-21T18:44:44ZengElsevierData in Brief2352-34092017-10-0114C14314710.1016/j.dib.2017.07.035Consensus datasets of mouse miRNA-mRNA interactions from multiple online resourcesZhao BiBin XueMiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been done on miRNA:mRNA interactions. Nonetheless, the interactions from different sources are not always consistent. In this study, we integrated multiple online resources, including mirTarBase, TarBase, miRanda, miRDB, PITA, and TargetScan, and developed eleven large-scale datasets containing miRNA:mRNA interactions that are consistent among a specific subgroup of above-mentioned online resources. In addition, a new integrated confidence score was designed to show the significance for all the miRNA:mRNA interactions.http://www.sciencedirect.com/science/article/pii/S2352340917303372 |
| spellingShingle | Zhao Bi Bin Xue Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources Data in Brief |
| title | Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources |
| title_full | Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources |
| title_fullStr | Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources |
| title_full_unstemmed | Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources |
| title_short | Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources |
| title_sort | consensus datasets of mouse mirna mrna interactions from multiple online resources |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917303372 |
| work_keys_str_mv | AT zhaobi consensusdatasetsofmousemirnamrnainteractionsfrommultipleonlineresources AT binxue consensusdatasetsofmousemirnamrnainteractionsfrommultipleonlineresources |