Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient
Retinoblastoma (RB) is a common intraocular malignancy mostly caused by variation of the tumour suppressor gene RB1. In this study, we successfully generated two induced pluripotent stem cell (iPSC) lines from an infant with non-heritable RB. Both cell clones exhibited typical iPSC characteristics w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123001861 |
| _version_ | 1797642605374210048 |
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| author | Ping Xu Fuying Guo Wei Xiao Yuan Wang Ke Ye Yuxiang Mao Xiufeng Zhong |
| author_facet | Ping Xu Fuying Guo Wei Xiao Yuan Wang Ke Ye Yuxiang Mao Xiufeng Zhong |
| author_sort | Ping Xu |
| collection | DOAJ |
| description | Retinoblastoma (RB) is a common intraocular malignancy mostly caused by variation of the tumour suppressor gene RB1. In this study, we successfully generated two induced pluripotent stem cell (iPSC) lines from an infant with non-heritable RB. Both cell clones exhibited typical iPSC characteristics with normal karyotypes, consistent pluripotency markers expression and the capability of trilineage differentiation. |
| first_indexed | 2024-03-11T14:02:26Z |
| format | Article |
| id | doaj.art-d6ec8cff4da1478f93aece41d3337dfb |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-11T14:02:26Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-d6ec8cff4da1478f93aece41d3337dfb2023-11-02T04:13:27ZengElsevierStem Cell Research1873-50612023-10-0172103200Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patientPing Xu0Fuying Guo1Wei Xiao2Yuan Wang3Ke Ye4Yuxiang Mao5Xiufeng Zhong6State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaCorresponding author.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, ChinaRetinoblastoma (RB) is a common intraocular malignancy mostly caused by variation of the tumour suppressor gene RB1. In this study, we successfully generated two induced pluripotent stem cell (iPSC) lines from an infant with non-heritable RB. Both cell clones exhibited typical iPSC characteristics with normal karyotypes, consistent pluripotency markers expression and the capability of trilineage differentiation.http://www.sciencedirect.com/science/article/pii/S1873506123001861 |
| spellingShingle | Ping Xu Fuying Guo Wei Xiao Yuan Wang Ke Ye Yuxiang Mao Xiufeng Zhong Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient Stem Cell Research |
| title | Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| title_full | Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| title_fullStr | Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| title_full_unstemmed | Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| title_short | Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| title_sort | generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123001861 |
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