Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach
Abstract Background To investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement. Methods Healthy subjects and central serous chorioretinopathy (CSC) patients were recruited for macular SS-OCTA scans. W...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01591-x |
| _version_ | 1818418622319558656 |
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| author | Erqian Wang Xinyu Zhao Jingyuan Yang Youxin Chen |
| author_facet | Erqian Wang Xinyu Zhao Jingyuan Yang Youxin Chen |
| author_sort | Erqian Wang |
| collection | DOAJ |
| description | Abstract Background To investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement. Methods Healthy subjects and central serous chorioretinopathy (CSC) patients were recruited for macular SS-OCTA scans. We evaluated OCTA images at various depths to determine an optimal depth for visualizing choroidal vasculatures. We measured CVD with binarized OCTA images at the optimal depth. In healthy subjects, CVD was studied for its correlation with age, axial length (AL), and subfoveal choroidal thickness (SCT). In CSC eyes, CVD was compared with matched controls. Results Ninety-one healthy eyes and 22 CSC eyes were included. SS-OCTA could display deep choroidal vasculatures as dark signals, with 100 μm beneath BM as the optimal depth. In healthy subjects, the CVD at 100 μm beneath BM (56.5 ± 10.9%) was significantly correlated with SCT (P = 0.004) but not with age (P = 0.49) or AL (P = 0.72). In CSC eyes, the CVD at 100 μm beneath BM (62.3 ± 6.6%) was larger than that in 22 matched controls (54.1 ± 8.0%) (P = 0.001). The difference remained statistically significant after adjusting for SCT (P = 0.02). Conclusions SS-OCTA can be used for visualizing deep choroidal vasculatures. CVD measured by OCTA at 100 μm beneath BM is a useful parameter for quantifying choroidal vascular status. |
| first_indexed | 2024-12-14T12:25:36Z |
| format | Article |
| id | doaj.art-d6eccb2bee2f46a7b86b286dea18e025 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-14T12:25:36Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-d6eccb2bee2f46a7b86b286dea18e0252022-12-21T23:01:20ZengBMCBMC Ophthalmology1471-24152020-08-012011910.1186/s12886-020-01591-xVisualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approachErqian Wang0Xinyu Zhao1Jingyuan Yang2Youxin Chen3Key Laboratory of Ocular Fundus Disease, Chinese Academy of Medical SciencesKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical SciencesKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical SciencesKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical SciencesAbstract Background To investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement. Methods Healthy subjects and central serous chorioretinopathy (CSC) patients were recruited for macular SS-OCTA scans. We evaluated OCTA images at various depths to determine an optimal depth for visualizing choroidal vasculatures. We measured CVD with binarized OCTA images at the optimal depth. In healthy subjects, CVD was studied for its correlation with age, axial length (AL), and subfoveal choroidal thickness (SCT). In CSC eyes, CVD was compared with matched controls. Results Ninety-one healthy eyes and 22 CSC eyes were included. SS-OCTA could display deep choroidal vasculatures as dark signals, with 100 μm beneath BM as the optimal depth. In healthy subjects, the CVD at 100 μm beneath BM (56.5 ± 10.9%) was significantly correlated with SCT (P = 0.004) but not with age (P = 0.49) or AL (P = 0.72). In CSC eyes, the CVD at 100 μm beneath BM (62.3 ± 6.6%) was larger than that in 22 matched controls (54.1 ± 8.0%) (P = 0.001). The difference remained statistically significant after adjusting for SCT (P = 0.02). Conclusions SS-OCTA can be used for visualizing deep choroidal vasculatures. CVD measured by OCTA at 100 μm beneath BM is a useful parameter for quantifying choroidal vascular status.http://link.springer.com/article/10.1186/s12886-020-01591-xOptical coherence tomography angiographySwept-sourceChoroidal vascular densitySubfoveal choroidal thicknessCentral serous chorioretinopathy |
| spellingShingle | Erqian Wang Xinyu Zhao Jingyuan Yang Youxin Chen Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach BMC Ophthalmology Optical coherence tomography angiography Swept-source Choroidal vascular density Subfoveal choroidal thickness Central serous chorioretinopathy |
| title | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach |
| title_full | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach |
| title_fullStr | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach |
| title_full_unstemmed | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach |
| title_short | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach |
| title_sort | visualization of deep choroidal vasculatures and measurement of choroidal vascular density a swept source optical coherence tomography angiography approach |
| topic | Optical coherence tomography angiography Swept-source Choroidal vascular density Subfoveal choroidal thickness Central serous chorioretinopathy |
| url | http://link.springer.com/article/10.1186/s12886-020-01591-x |
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