Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women
Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1. Materials and Methods: This case-control study was conducted on 120 women with...
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Hamadan University of Medical Sciences
2021-09-01
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| Series: | پزشکی بالینی ابن سینا |
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| Online Access: | http://sjh.umsha.ac.ir/article-1-2252-en.html |
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| author | Mahsa Yousefian Seyed Abdolhamid Angaji Elham Siasi Seyed Ali Rahmani Shamci Abbasalizadeh Khiaban |
| author_facet | Mahsa Yousefian Seyed Abdolhamid Angaji Elham Siasi Seyed Ali Rahmani Shamci Abbasalizadeh Khiaban |
| author_sort | Mahsa Yousefian |
| collection | DOAJ |
| description | Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1.
Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplification-refractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chi-squared test (P˂0.05).
Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0.222; 95%CI=0.082-0.599); nonetheless,
no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0.488-2.049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0.245; 95% CI=0.066-0.901).
Conclusion: As evidenced by the obtained results, there was a protective association between rs6090 and RPL; nonetheless, there was no relationship between rs3136520 and RPL. |
| first_indexed | 2024-12-17T01:43:43Z |
| format | Article |
| id | doaj.art-d6f1ddf606264cca9389effb7cdc8a7f |
| institution | Directory Open Access Journal |
| issn | 2588-722X 2588-7238 |
| language | fas |
| last_indexed | 2024-12-17T01:43:43Z |
| publishDate | 2021-09-01 |
| publisher | Hamadan University of Medical Sciences |
| record_format | Article |
| series | پزشکی بالینی ابن سینا |
| spelling | doaj.art-d6f1ddf606264cca9389effb7cdc8a7f2022-12-21T22:08:15ZfasHamadan University of Medical Sciencesپزشکی بالینی ابن سینا2588-722X2588-72382021-09-01282118125Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri WomenMahsa Yousefian0Seyed Abdolhamid Angaji1Elham Siasi2Seyed Ali Rahmani3Shamci Abbasalizadeh Khiaban4 PhD Candidate, Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran Associate Professor, Department of Cell and Molecular Biology, School of Biological Sciences, Kharazmi University, Tehran, Iran Assistant Professor, Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran Assistant Professor, Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Professor, Department of Obstetrics & Gynecology, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1. Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplification-refractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chi-squared test (P˂0.05). Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0.222; 95%CI=0.082-0.599); nonetheless, no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0.488-2.049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0.245; 95% CI=0.066-0.901). Conclusion: As evidenced by the obtained results, there was a protective association between rs6090 and RPL; nonetheless, there was no relationship between rs3136520 and RPL.http://sjh.umsha.ac.ir/article-1-2252-en.html: coagulation factorsplasminogen activator inhibitor 1recurrent abortionthrombophilia |
| spellingShingle | Mahsa Yousefian Seyed Abdolhamid Angaji Elham Siasi Seyed Ali Rahmani Shamci Abbasalizadeh Khiaban Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women پزشکی بالینی ابن سینا : coagulation factors plasminogen activator inhibitor 1 recurrent abortion thrombophilia |
| title | Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women |
| title_full | Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women |
| title_fullStr | Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women |
| title_full_unstemmed | Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women |
| title_short | Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women |
| title_sort | association of polymorphisms of f2 rs3136520 and pai 1 rs6090 genes with recurrent pregnancy loss in iranian azeri women |
| topic | : coagulation factors plasminogen activator inhibitor 1 recurrent abortion thrombophilia |
| url | http://sjh.umsha.ac.ir/article-1-2252-en.html |
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