LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells

LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells

Abstract Background Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiatio...

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Bibliographic Details
Main Authors: Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang, Fu-Rong Li
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cells
Differentiation
Insulin-producing cells
Lysine-specific demethylase 1(LSD1)
Online Access:http://link.springer.com/article/10.1186/s13287-020-01674-y

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