Novel and Practical Industrial Process Scale-Up of 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid, a Key Intermediate in the Manufacturing of Therapeutic SGLT2 Inhibitors

Novel and Practical Industrial Process Scale-Up of 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid, a Key Intermediate in the Manufacturing of Therapeutic SGLT2 Inhibitors

Abstract 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid (1) is a key intermediate for the synthesis of a family of promising SGLT2 inhibitors currently in preclinical and phase I studies for diabetes therapy. In this investigation, cheap, easily available dimethyl terephthalate was used...

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Bibliographic Details
Main Authors: Yi Zhang, Xiao Ma, Xiao-Hui Shan, Xiao-Wen Zhang, Jian-Qi Li, Yu Liu
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-12-01
Series:Pharmaceutical Fronts
Subjects:
5-bromo-2-chloro-4-(methoxycarbonyl)benzoic acid
sglt2 inhibitors
practical process
scale up
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1755195

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