The surging role of Chromogranin A in cardiovascular homeostasis
Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, sever...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00064/full |
| _version_ | 1818452731116912640 |
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| author | BRUNO eTOTA TOMMASO eANGELONE MARIA CARMELA CERRA |
| author_facet | BRUNO eTOTA TOMMASO eANGELONE MARIA CARMELA CERRA |
| author_sort | BRUNO eTOTA |
| collection | DOAJ |
| description | Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker of the sympatho-adrenal neuroendocrine activity. Due to its partial processing to several biologically active peptides, CGA appears an important pro-hormone implicated in relevant modulatory actions on endocrine, cardiovascular, metabolic, and immune systems through both direct and indirect sympatho-adrenergic interactions. As a part of this scenario, we here illustrate the emerging role exerted by the full-length CGA and its three derived fragments, i.e. Vasostatin 1, catestatin and serpinin, in the control of circulatory homeostasis with particular emphasis on their cardio-vascular actions under both physiological and physio-pathological conditions. The Vasostatin 1- and catestatin-induced cardiodepressive influences are achieved through anti-beta-adrenergic-NO-cGMP signalling, while serpinin acts like beta1-adrenergic agonist through AD-cAMP-independent NO signalling. On the whole, these actions contribute to wide our knowledge regarding the sympatho-chromaffin control of the cardiovascular system and its highly integrated whip-brake networks. |
| first_indexed | 2024-12-14T21:27:45Z |
| format | Article |
| id | doaj.art-d6f2c1a7b6d943898d074651b6125c59 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-14T21:27:45Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-d6f2c1a7b6d943898d074651b6125c592022-12-21T22:46:45ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462014-08-01210.3389/fchem.2014.00064107355The surging role of Chromogranin A in cardiovascular homeostasisBRUNO eTOTA0TOMMASO eANGELONE1MARIA CARMELA CERRA2UNIVERSITY OF CALABRIAUNIVERSITY OF CALABRIAUNIVERSITY OF CALABRIATogether with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker of the sympatho-adrenal neuroendocrine activity. Due to its partial processing to several biologically active peptides, CGA appears an important pro-hormone implicated in relevant modulatory actions on endocrine, cardiovascular, metabolic, and immune systems through both direct and indirect sympatho-adrenergic interactions. As a part of this scenario, we here illustrate the emerging role exerted by the full-length CGA and its three derived fragments, i.e. Vasostatin 1, catestatin and serpinin, in the control of circulatory homeostasis with particular emphasis on their cardio-vascular actions under both physiological and physio-pathological conditions. The Vasostatin 1- and catestatin-induced cardiodepressive influences are achieved through anti-beta-adrenergic-NO-cGMP signalling, while serpinin acts like beta1-adrenergic agonist through AD-cAMP-independent NO signalling. On the whole, these actions contribute to wide our knowledge regarding the sympatho-chromaffin control of the cardiovascular system and its highly integrated whip-brake networks.http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00064/fullChromogranin ACardioprotectionVasostatin 1CatestatinSerpininadreno-sympathetic control |
| spellingShingle | BRUNO eTOTA TOMMASO eANGELONE MARIA CARMELA CERRA The surging role of Chromogranin A in cardiovascular homeostasis Frontiers in Chemistry Chromogranin A Cardioprotection Vasostatin 1 Catestatin Serpinin adreno-sympathetic control |
| title | The surging role of Chromogranin A in cardiovascular homeostasis |
| title_full | The surging role of Chromogranin A in cardiovascular homeostasis |
| title_fullStr | The surging role of Chromogranin A in cardiovascular homeostasis |
| title_full_unstemmed | The surging role of Chromogranin A in cardiovascular homeostasis |
| title_short | The surging role of Chromogranin A in cardiovascular homeostasis |
| title_sort | surging role of chromogranin a in cardiovascular homeostasis |
| topic | Chromogranin A Cardioprotection Vasostatin 1 Catestatin Serpinin adreno-sympathetic control |
| url | http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00064/full |
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