Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis
AIM: To compare the effectiveness of two well described machine learning modalities, ocular coherence tomography (OCT) and fundal photography, in terms of diagnostic accuracy in the screening and diagnosis of glaucoma. METHODS: A systematic search of Embase and PubMed databases was undertaken up to...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2020-01-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ijo.cn/en_publish/2020/1/20200122.pdf |
| _version_ | 1819084775380484096 |
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| author | Patrick Murtagh Garrett Greene Colm O'Brien |
| author_facet | Patrick Murtagh Garrett Greene Colm O'Brien |
| author_sort | Patrick Murtagh |
| collection | DOAJ |
| description | AIM: To compare the effectiveness of two well described machine learning modalities, ocular coherence tomography (OCT) and fundal photography, in terms of diagnostic accuracy in the screening and diagnosis of glaucoma.
METHODS: A systematic search of Embase and PubMed databases was undertaken up to 1st of February 2019. Articles were identified alongside their reference lists and relevant studies were aggregated. A Meta-analysis of diagnostic accuracy in terms of area under the receiver operating curve (AUROC) was performed. For the studies which did not report an AUROC, reported sensitivity and specificity values were combined to create a summary ROC curve which was included in the Meta-analysis.
RESULTS: A total of 23 studies were deemed suitable for inclusion in the Meta-analysis. This included 10 papers from the OCT cohort and 13 from the fundal photos cohort. Random effects Meta-analysis gave a pooled AUROC of 0.957 (95%CI=0.917 to 0.997) for fundal photos and 0.923 (95%CI=0.889 to 0.957) for the OCT cohort. The slightly higher accuracy of fundal photos methods is likely attributable to the much larger database of images used to train the models (59 788 vs 1743).
CONCLUSION: No demonstrable difference is shown between the diagnostic accuracy of the two modalities. The ease of access and lower cost associated with fundal photo acquisition make that the more appealing option in terms of screening on a global scale, however further studies need to be undertaken, owing largely to the poor study quality associated with the fundal photography cohort. |
| first_indexed | 2024-12-21T20:53:49Z |
| format | Article |
| id | doaj.art-d6f37ae4ff414f0aa1dd1d0bf338567b |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-21T20:53:49Z |
| publishDate | 2020-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-d6f37ae4ff414f0aa1dd1d0bf338567b2022-12-21T18:50:39ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982020-01-0113114916210.18240/ijo.2020.01.22Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysisPatrick Murtagh0Garrett Greene1Colm O'Brien2Department of Ophthalmology, Mater Misericordiae University Hospital, Eccles Street, Dublin D07 R2WY, IrelandRCSI Education and Research Centre, Beaumont Hospital, Dublin D05 AT88, IrelandDepartment of Ophthalmology, Mater Misericordiae University Hospital, Eccles Street, Dublin D07 R2WY, IrelandAIM: To compare the effectiveness of two well described machine learning modalities, ocular coherence tomography (OCT) and fundal photography, in terms of diagnostic accuracy in the screening and diagnosis of glaucoma. METHODS: A systematic search of Embase and PubMed databases was undertaken up to 1st of February 2019. Articles were identified alongside their reference lists and relevant studies were aggregated. A Meta-analysis of diagnostic accuracy in terms of area under the receiver operating curve (AUROC) was performed. For the studies which did not report an AUROC, reported sensitivity and specificity values were combined to create a summary ROC curve which was included in the Meta-analysis. RESULTS: A total of 23 studies were deemed suitable for inclusion in the Meta-analysis. This included 10 papers from the OCT cohort and 13 from the fundal photos cohort. Random effects Meta-analysis gave a pooled AUROC of 0.957 (95%CI=0.917 to 0.997) for fundal photos and 0.923 (95%CI=0.889 to 0.957) for the OCT cohort. The slightly higher accuracy of fundal photos methods is likely attributable to the much larger database of images used to train the models (59 788 vs 1743). CONCLUSION: No demonstrable difference is shown between the diagnostic accuracy of the two modalities. The ease of access and lower cost associated with fundal photo acquisition make that the more appealing option in terms of screening on a global scale, however further studies need to be undertaken, owing largely to the poor study quality associated with the fundal photography cohort.http://www.ijo.cn/en_publish/2020/1/20200122.pdfmachine learningglaucomaocular coherence tomographyfundal photographydiagnosismeta-analysis |
| spellingShingle | Patrick Murtagh Garrett Greene Colm O'Brien Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis International Journal of Ophthalmology machine learning glaucoma ocular coherence tomography fundal photography diagnosis meta-analysis |
| title | Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis |
| title_full | Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis |
| title_fullStr | Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis |
| title_full_unstemmed | Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis |
| title_short | Current applications of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis |
| title_sort | current applications of machine learning in the screening and diagnosis of glaucoma a systematic review and meta analysis |
| topic | machine learning glaucoma ocular coherence tomography fundal photography diagnosis meta-analysis |
| url | http://www.ijo.cn/en_publish/2020/1/20200122.pdf |
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