Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex
Effects of local administration of atropine into the medial septal nucleus (MSN) and dorsal septal nucleus (DSN) were tested in laboratory rats. Atropine administration led to the development of a spike/wave activity in the hippocampus as well as amygdala within 10 minutes. The frequency of spikes r...
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| Format: | Article |
| Language: | English |
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Karolinum Press
1998-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/41/3/0131/ |
| _version_ | 1817989483878940672 |
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| author | Josef Herink |
| author_facet | Josef Herink |
| author_sort | Josef Herink |
| collection | DOAJ |
| description | Effects of local administration of atropine into the medial septal nucleus (MSN) and dorsal septal nucleus (DSN) were tested in laboratory rats. Atropine administration led to the development of a spike/wave activity in the hippocampus as well as amygdala within 10 minutes. The frequency of spikes ranged in the absolute values from 20 to 25 spikes per minute in the case of atropine administration to MSN, while in the case of DSN it reached only about 16 spikes per minute. Spike/wave activity outlasted in the EEG record within 2 hours. The average incidence of spikes was somewhat lower in females than in males. A possible relation of the atropine-induced spike/wave activity to another kinds of limbic convulsions is discussed. |
| first_indexed | 2024-04-14T00:47:26Z |
| format | Article |
| id | doaj.art-d6f443a69dbe4a07a2199179b9072ae1 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-14T00:47:26Z |
| publishDate | 1998-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-d6f443a69dbe4a07a2199179b9072ae12022-12-22T02:21:58ZengKarolinum PressActa Medica1211-42861805-96941998-01-0141313113410.14712/18059694.2019.177Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and SexJosef Herink0Purkyně Military Medical Academy, Hradec Králové, Czech RepublicEffects of local administration of atropine into the medial septal nucleus (MSN) and dorsal septal nucleus (DSN) were tested in laboratory rats. Atropine administration led to the development of a spike/wave activity in the hippocampus as well as amygdala within 10 minutes. The frequency of spikes ranged in the absolute values from 20 to 25 spikes per minute in the case of atropine administration to MSN, while in the case of DSN it reached only about 16 spikes per minute. Spike/wave activity outlasted in the EEG record within 2 hours. The average incidence of spikes was somewhat lower in females than in males. A possible relation of the atropine-induced spike/wave activity to another kinds of limbic convulsions is discussed.https://actamedica.lfhk.cuni.cz/41/3/0131/AtropineConvulsionsRatSeptohippocampal system |
| spellingShingle | Josef Herink Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex Acta Medica Atropine Convulsions Rat Septohippocampal system |
| title | Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex |
| title_full | Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex |
| title_fullStr | Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex |
| title_full_unstemmed | Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex |
| title_short | Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex |
| title_sort | atropine induced convulsions in the septohippocampal system i effects of cannula position and sex |
| topic | Atropine Convulsions Rat Septohippocampal system |
| url | https://actamedica.lfhk.cuni.cz/41/3/0131/ |
| work_keys_str_mv | AT josefherink atropineinducedconvulsionsintheseptohippocampalsystemieffectsofcannulapositionandsex |