Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients
Several risk prediction models of Contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiac angiography or angioplasty are available. However, the lack of extensive external validations limits generalizability and clinical acceptance. This study conducted the external validatio...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Mahidol University
2022-09-01
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| Series: | Pharmaceutical Sciences Asia |
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| Online Access: | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-5_13.pdf |
| _version_ | 1818054948815896576 |
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| author | Sinwisuth Sutheechai Khanittha Lailakdamrong Patcharaporn Sudchada |
| author_facet | Sinwisuth Sutheechai Khanittha Lailakdamrong Patcharaporn Sudchada |
| author_sort | Sinwisuth Sutheechai |
| collection | DOAJ |
| description | Several risk prediction models of Contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiac angiography or angioplasty are available. However, the lack of extensive external validations limits generalizability and clinical acceptance. This study conducted the external validation of three CA-AKI predictive risk models (Chen’s, Inohara’s, and Tziakas’ risk models) and determined the incidence of CA-AKI in Thai patients undergoing cardiac angiography or angioplasty. A total of 647 medical records of patients who underwent elective cardiac angiography (n=446) and angioplasty (n=201) were reviewed. Fifty-five percent were male, mean age 62.6±10.2 years, and mean estimated glomerular filtration rate (eGFR) 69.93±24.30 ml/min/1.73 m2). Incidents of CA-AKI, defined as an absolute increase of serum creatinine of at least 0.3 mg/dL within 48 hours or a relative increase of at least 50% within seven days after the procedure, were collected. The results showed that 78 patients (12.1%) had developed CA-AKI. Chen’s, Inohara’s, and Tziakas’ predictive risk models exhibited low discriminative ability with c-statistic of 0.571, 0.551, and 0.530, respectively. Due to low discriminative capability, these risk models may have low sensitivity to predict CA-AKI in Thai patients undergoing elective cardiac angiography or angioplasty. |
| first_indexed | 2024-12-10T12:05:10Z |
| format | Article |
| id | doaj.art-d6f580ce1a644a53b2f306aaaa1aae2f |
| institution | Directory Open Access Journal |
| issn | 2586-8470 |
| language | English |
| last_indexed | 2024-12-10T12:05:10Z |
| publishDate | 2022-09-01 |
| publisher | Faculty of Pharmacy, Mahidol University |
| record_format | Article |
| series | Pharmaceutical Sciences Asia |
| spelling | doaj.art-d6f580ce1a644a53b2f306aaaa1aae2f2022-12-22T01:49:29ZengFaculty of Pharmacy, Mahidol UniversityPharmaceutical Sciences Asia2586-84702022-09-0149551852510.29090/psa.2022.05.22.175Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patientsSinwisuth Sutheechai0Khanittha Lailakdamrong1Patcharaporn Sudchada2Department of Pharmaceutical care, Faculty of Pharmacy, Chiang Mai University, ThailandCardiac Institute, Saint Louis Hospital, Bangkok, ThailandDepartment of Pharmacy Practice, Faculty of Pharmaceutical sciences, Naresuan University, ThailandSeveral risk prediction models of Contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiac angiography or angioplasty are available. However, the lack of extensive external validations limits generalizability and clinical acceptance. This study conducted the external validation of three CA-AKI predictive risk models (Chen’s, Inohara’s, and Tziakas’ risk models) and determined the incidence of CA-AKI in Thai patients undergoing cardiac angiography or angioplasty. A total of 647 medical records of patients who underwent elective cardiac angiography (n=446) and angioplasty (n=201) were reviewed. Fifty-five percent were male, mean age 62.6±10.2 years, and mean estimated glomerular filtration rate (eGFR) 69.93±24.30 ml/min/1.73 m2). Incidents of CA-AKI, defined as an absolute increase of serum creatinine of at least 0.3 mg/dL within 48 hours or a relative increase of at least 50% within seven days after the procedure, were collected. The results showed that 78 patients (12.1%) had developed CA-AKI. Chen’s, Inohara’s, and Tziakas’ predictive risk models exhibited low discriminative ability with c-statistic of 0.571, 0.551, and 0.530, respectively. Due to low discriminative capability, these risk models may have low sensitivity to predict CA-AKI in Thai patients undergoing elective cardiac angiography or angioplasty.https://pharmacy.mahidol.ac.th/journal/_files/2022-49-5_13.pdfcontrast mediacontrast-associated acute kidney injurynephropathyangiographyangioplastypercutaneous coronary intervention |
| spellingShingle | Sinwisuth Sutheechai Khanittha Lailakdamrong Patcharaporn Sudchada Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients Pharmaceutical Sciences Asia contrast media contrast-associated acute kidney injury nephropathy angiography angioplasty percutaneous coronary intervention |
| title | Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients |
| title_full | Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients |
| title_fullStr | Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients |
| title_full_unstemmed | Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients |
| title_short | Performance of contrast-associated acute kidney injury predictive risk models in Thai cardiac angiography or angioplasty patients |
| title_sort | performance of contrast associated acute kidney injury predictive risk models in thai cardiac angiography or angioplasty patients |
| topic | contrast media contrast-associated acute kidney injury nephropathy angiography angioplasty percutaneous coronary intervention |
| url | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-5_13.pdf |
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