Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways

Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways

The protective effects and mechanisms of dioscin against liver fibrosis were investigated. The results showed that dioscin markedly suppressed the proliferation of HSC-T6 cells, but not to the isolated hepatocytes, down-regulated the levels of fibronectin, α-SMA, collagen and vimentin, and up-regula...

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Bibliographic Details
Main Authors: Xiaoling Zhang, Youwei Xu, Yan Qi, Xu Han, Lianhong Yin, Lina Xu, Kexin Liu, Jinyong Peng
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Functional Foods
Subjects:
Dioscin
Hepatoprotective effect
Hepatic stellate cell
Liver fibrosis
Thioacetamide
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615002376

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