Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i>
The intestine barrier, the front line of normal body defense, relies on its structural integrity, microbial composition and barrier immunity. The intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. Although it occupies a relatively small proportio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1910 |
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| author | Da Qin Yixuan Ma Yanhong Wang Xilin Hou Liyun Yu |
| author_facet | Da Qin Yixuan Ma Yanhong Wang Xilin Hou Liyun Yu |
| author_sort | Da Qin |
| collection | DOAJ |
| description | The intestine barrier, the front line of normal body defense, relies on its structural integrity, microbial composition and barrier immunity. The intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. Although it occupies a relatively small proportion of the intestinal microbiota, <i>Lactobacilli</i> has been discovered to have a significant impact on the intestine tract in previous studies. It is undeniable that some <i>Lactobacillus</i> strains present probiotic properties through maintaining the micro-ecological balance via different mechanisms, such as mucosal barrier function and barrier immunity, to prevent infection and even to solve some neurology issues by microbiota–gut–brain/liver/lung axis communication. Notably, not only living cells but also <i>Lactobacillus</i> derivatives (postbiotics: soluble secreted products and para-probiotics: cell structural components) may exert antipathogenic effects and beneficial functions for the gut mucosal barrier. However, substantial research on specific effects, safety and action mechanisms in vivo should be done. In clinical application of humans and animals, there are still doubts about the precise evaluation of <i>Lactobacilli</i>’s safety, therapeutic effect, dosage and other aspects. Therefore, we provide an overview of central issues on the impacts of <i>Lactobacillus casei</i> (<i>L. casei</i>) and their products on the intestinal mucosal barrier and some diseases and highlight the urgent need for further studies. |
| first_indexed | 2024-03-09T18:13:12Z |
| format | Article |
| id | doaj.art-d6f8c2b867f4468493fb7bdb06ba85b7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:13:12Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d6f8c2b867f4468493fb7bdb06ba85b72023-11-24T08:57:55ZengMDPI AGLife2075-17292022-11-011211191010.3390/life12111910Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i>Da Qin0Yixuan Ma1Yanhong Wang2Xilin Hou3Liyun Yu4Heilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaHeilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaHeilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaColleges of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaHeilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, ChinaThe intestine barrier, the front line of normal body defense, relies on its structural integrity, microbial composition and barrier immunity. The intestinal mucosal surface is continuously exposed to a complex and dynamic community of microorganisms. Although it occupies a relatively small proportion of the intestinal microbiota, <i>Lactobacilli</i> has been discovered to have a significant impact on the intestine tract in previous studies. It is undeniable that some <i>Lactobacillus</i> strains present probiotic properties through maintaining the micro-ecological balance via different mechanisms, such as mucosal barrier function and barrier immunity, to prevent infection and even to solve some neurology issues by microbiota–gut–brain/liver/lung axis communication. Notably, not only living cells but also <i>Lactobacillus</i> derivatives (postbiotics: soluble secreted products and para-probiotics: cell structural components) may exert antipathogenic effects and beneficial functions for the gut mucosal barrier. However, substantial research on specific effects, safety and action mechanisms in vivo should be done. In clinical application of humans and animals, there are still doubts about the precise evaluation of <i>Lactobacilli</i>’s safety, therapeutic effect, dosage and other aspects. Therefore, we provide an overview of central issues on the impacts of <i>Lactobacillus casei</i> (<i>L. casei</i>) and their products on the intestinal mucosal barrier and some diseases and highlight the urgent need for further studies.https://www.mdpi.com/2075-1729/12/11/1910<i>Lactobacillus</i>intestinal mucosal barrierGIT-related diseasesinnate immunity |
| spellingShingle | Da Qin Yixuan Ma Yanhong Wang Xilin Hou Liyun Yu Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> Life <i>Lactobacillus</i> intestinal mucosal barrier GIT-related diseases innate immunity |
| title | Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> |
| title_full | Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> |
| title_fullStr | Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> |
| title_full_unstemmed | Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> |
| title_short | Contribution of <i>Lactobacilli</i> on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of <i>Lactobacillus casei</i> |
| title_sort | contribution of i lactobacilli i on intestinal mucosal barrier and diseases perspectives and challenges of i lactobacillus casei i |
| topic | <i>Lactobacillus</i> intestinal mucosal barrier GIT-related diseases innate immunity |
| url | https://www.mdpi.com/2075-1729/12/11/1910 |
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