Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
Objective(s):Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ)-induced diabetic rats. Recently, the effects of naringin on lea...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-04-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_6814_d71e3e0f47caa92c077f2b66ba92bcc1.pdf |
| _version_ | 1811315740025815040 |
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| author | Xianchu Liu Ming Liu Yanzhi Mo Huan Peng Jingbo Gong Zhuang Li Jiaxue Chen Jingtao Xie |
| author_facet | Xianchu Liu Ming Liu Yanzhi Mo Huan Peng Jingbo Gong Zhuang Li Jiaxue Chen Jingtao Xie |
| author_sort | Xianchu Liu |
| collection | DOAJ |
| description | Objective(s):Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ)-induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. However, to date, no studies have investigated the ameliorative effects of naringin on diabetes-associated cognitive decline (DACD). In this study, we investigated the effects of naringin, using a STZ-injected rat model and explored its potential mechanism. Materials and Methods:Diabetic rats were treated with naringin (100 mg/kg/d) for 7 days. The learning and memory function were assessed by Morris water maze test. The oxidative stress indicators [superoxide dismutase (SOD) and malondialdehyde (MDA)] and inflammatory cytokines (TNF-a, IL-1β, and IL-6) were measured in hippocampus using corresponding commercial kits. The mRNA and protein levels of PPARγ were evaluated by real time (RT)-PCR and Western blot analysis. Results:The results showed that supplementation of naringin improved learning and memory performances compared with the STZ group. Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-α, IL-1β, and IL-6 compared with the STZ group in the hippocampus. The pretreatment with naringin also significantly increased PPARγ expression. Conclusion: Our results showed that naringin may be a promising therapeutic agent for improving cognitive decline in DACD. |
| first_indexed | 2024-04-13T11:35:44Z |
| format | Article |
| id | doaj.art-d6f9f73738e94aaca93ab573776178dc |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T11:35:44Z |
| publishDate | 2016-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-d6f9f73738e94aaca93ab573776178dc2022-12-22T02:48:27ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-04-011944174226814Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic ratsXianchu Liu0Ming Liu1Yanzhi Mo2Huan Peng3Jingbo Gong4Zhuang Li5Jiaxue Chen6Jingtao Xie7Department of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaDepartment of Applied Psychology, Hunan University of Chinese Medicine, Hunan, PR ChinaObjective(s):Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ)-induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. However, to date, no studies have investigated the ameliorative effects of naringin on diabetes-associated cognitive decline (DACD). In this study, we investigated the effects of naringin, using a STZ-injected rat model and explored its potential mechanism. Materials and Methods:Diabetic rats were treated with naringin (100 mg/kg/d) for 7 days. The learning and memory function were assessed by Morris water maze test. The oxidative stress indicators [superoxide dismutase (SOD) and malondialdehyde (MDA)] and inflammatory cytokines (TNF-a, IL-1β, and IL-6) were measured in hippocampus using corresponding commercial kits. The mRNA and protein levels of PPARγ were evaluated by real time (RT)-PCR and Western blot analysis. Results:The results showed that supplementation of naringin improved learning and memory performances compared with the STZ group. Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-α, IL-1β, and IL-6 compared with the STZ group in the hippocampus. The pretreatment with naringin also significantly increased PPARγ expression. Conclusion: Our results showed that naringin may be a promising therapeutic agent for improving cognitive decline in DACD.http://ijbms.mums.ac.ir/article_6814_d71e3e0f47caa92c077f2b66ba92bcc1.pdfCognitiveDACDInflammationNaringinOxidative stressPPARγ |
| spellingShingle | Xianchu Liu Ming Liu Yanzhi Mo Huan Peng Jingbo Gong Zhuang Li Jiaxue Chen Jingtao Xie Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats Iranian Journal of Basic Medical Sciences Cognitive DACD Inflammation Naringin Oxidative stress PPARγ |
| title | Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats |
| title_full | Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats |
| title_fullStr | Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats |
| title_short | Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats |
| title_sort | naringin ameliorates cognitive deficits in streptozotocin induced diabetic rats |
| topic | Cognitive DACD Inflammation Naringin Oxidative stress PPARγ |
| url | http://ijbms.mums.ac.ir/article_6814_d71e3e0f47caa92c077f2b66ba92bcc1.pdf |
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