Innate Lymphocytes in Inflammatory Arthritis
Inflammatory arthritis (IA) refers to a group of chronic diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and other spondyloarthritis (SpA). IA is characterized by autoimmune-mediated joint inflammation and is associated with inflammatory cytokin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.565275/full |
| _version_ | 1818137730686648320 |
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| author | Xunyao Wu |
| author_facet | Xunyao Wu |
| author_sort | Xunyao Wu |
| collection | DOAJ |
| description | Inflammatory arthritis (IA) refers to a group of chronic diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and other spondyloarthritis (SpA). IA is characterized by autoimmune-mediated joint inflammation and is associated with inflammatory cytokine networks. Innate lymphocytes, including innate-like lymphocytes (ILLs) expressing T or B cell receptors and innate lymphoid cells (ILCs), play important roles in the initiation of host immune responses against self-antigens and rapidly produce large amounts of cytokines upon stimulation. TNF (Tumor Necrosis Factor)-α, IFN (Interferon)-γ, Th2-related cytokines (IL-4, IL-9, IL-10, and IL-13), IL-17A, IL-22, and GM-CSF are involved in IA and are secreted by ILLs and ILCs. In this review, we focus on the current knowledge of ILL and ILC phenotypes, cytokine production and functions in IA. A better understanding of the roles of ILLs and ILCs in IA initiation and development will ultimately provide insights into developing effective strategies for the clinical treatment of IA patients. |
| first_indexed | 2024-12-11T10:00:57Z |
| format | Article |
| id | doaj.art-d6fa0ce1a13241bf88df9270e7334bda |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T10:00:57Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d6fa0ce1a13241bf88df9270e7334bda2022-12-22T01:12:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.565275565275Innate Lymphocytes in Inflammatory ArthritisXunyao WuInflammatory arthritis (IA) refers to a group of chronic diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and other spondyloarthritis (SpA). IA is characterized by autoimmune-mediated joint inflammation and is associated with inflammatory cytokine networks. Innate lymphocytes, including innate-like lymphocytes (ILLs) expressing T or B cell receptors and innate lymphoid cells (ILCs), play important roles in the initiation of host immune responses against self-antigens and rapidly produce large amounts of cytokines upon stimulation. TNF (Tumor Necrosis Factor)-α, IFN (Interferon)-γ, Th2-related cytokines (IL-4, IL-9, IL-10, and IL-13), IL-17A, IL-22, and GM-CSF are involved in IA and are secreted by ILLs and ILCs. In this review, we focus on the current knowledge of ILL and ILC phenotypes, cytokine production and functions in IA. A better understanding of the roles of ILLs and ILCs in IA initiation and development will ultimately provide insights into developing effective strategies for the clinical treatment of IA patients.https://www.frontiersin.org/article/10.3389/fimmu.2020.565275/fullInflammatory arthritisinnate-like lymphocytesinnate lymphoid cellsinflammatory cytokineNK cells |
| spellingShingle | Xunyao Wu Innate Lymphocytes in Inflammatory Arthritis Frontiers in Immunology Inflammatory arthritis innate-like lymphocytes innate lymphoid cells inflammatory cytokine NK cells |
| title | Innate Lymphocytes in Inflammatory Arthritis |
| title_full | Innate Lymphocytes in Inflammatory Arthritis |
| title_fullStr | Innate Lymphocytes in Inflammatory Arthritis |
| title_full_unstemmed | Innate Lymphocytes in Inflammatory Arthritis |
| title_short | Innate Lymphocytes in Inflammatory Arthritis |
| title_sort | innate lymphocytes in inflammatory arthritis |
| topic | Inflammatory arthritis innate-like lymphocytes innate lymphoid cells inflammatory cytokine NK cells |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.565275/full |
| work_keys_str_mv | AT xunyaowu innatelymphocytesininflammatoryarthritis |