Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review
Apart from conjunctival involvement which is the most well-known ocular manifestation of coronavirus infectious disease 2019 (COVID-19), there are multiple reports of the involvement of other ocular structures by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We comprehensively review...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2021-05-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v16i2.9087 |
| _version_ | 1798046417804066816 |
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| author | Amirhossein Roshanshad Mohammad Ali Ashraf Romina Roshanshad Ali Kharmandar Seyed Alireza Zomorodian Hossein Ashraf |
| author_facet | Amirhossein Roshanshad Mohammad Ali Ashraf Romina Roshanshad Ali Kharmandar Seyed Alireza Zomorodian Hossein Ashraf |
| author_sort | Amirhossein Roshanshad |
| collection | DOAJ |
| description | Apart from conjunctival involvement which is the most well-known ocular manifestation of coronavirus infectious disease 2019 (COVID-19), there are multiple reports of the involvement of other ocular structures by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We comprehensively reviewed PubMed, Scopus, Embase, and Google Scholar for available evidence regarding COVID-19 various ocular manifestations, with special focus on less known and unusual ocular findings. We then categorized the findings based on the parts of the eye which was involved. In anterior sections of the eye, the involvement of the eyelid (tarsadenitis), conjunctiva and cornea (follicular conjunctivitis, pseudomembranous conjunctivitis, and keratoconjunctivitis), episclera (nodular episcleritis), uvea (anterior uveitis) were reported. Also, third, fourth, and sixth nerve palsy, retinal vasculitis, retinal optical coherence tomography (OCT) changes (hyper-reflective lesions and increased retinal nerve fiber layer thickness [RNFLT]), optic neuritis, papillophlebitis, Miller Fisher syndrome, posterior reversible leukoencephalopathy (PRES), ophthalmic artery and central retinal artery occlusion, and polyneuritis cranialis were reported in different studies. Postmortem evaluation of COVID-19 patients detected no viral RNA in different anterior and posterior segments of the eyes. However, another study revealed a 21.4% positivity of the retinal biopsies of dead patients. The results of this study can help ophthalmologists to be vigilant when they see these findings in a suspected case of COVID-19. In addition, wearing face masks and protective goggles or eye shields are recommended, especially in high risk contacts. |
| first_indexed | 2024-04-11T23:37:13Z |
| format | Article |
| id | doaj.art-d6fa2b81821f4e859f9d204eec8824e6 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T23:37:13Z |
| publishDate | 2021-05-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-d6fa2b81821f4e859f9d204eec8824e62022-12-22T03:56:54ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2021-05-011623424710.18502/jovr.v16i2.9087Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive ReviewAmirhossein Roshanshad0Mohammad Ali Ashraf1Romina Roshanshad2Ali Kharmandar3Seyed Alireza Zomorodian4Hossein Ashraf5 Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranApart from conjunctival involvement which is the most well-known ocular manifestation of coronavirus infectious disease 2019 (COVID-19), there are multiple reports of the involvement of other ocular structures by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We comprehensively reviewed PubMed, Scopus, Embase, and Google Scholar for available evidence regarding COVID-19 various ocular manifestations, with special focus on less known and unusual ocular findings. We then categorized the findings based on the parts of the eye which was involved. In anterior sections of the eye, the involvement of the eyelid (tarsadenitis), conjunctiva and cornea (follicular conjunctivitis, pseudomembranous conjunctivitis, and keratoconjunctivitis), episclera (nodular episcleritis), uvea (anterior uveitis) were reported. Also, third, fourth, and sixth nerve palsy, retinal vasculitis, retinal optical coherence tomography (OCT) changes (hyper-reflective lesions and increased retinal nerve fiber layer thickness [RNFLT]), optic neuritis, papillophlebitis, Miller Fisher syndrome, posterior reversible leukoencephalopathy (PRES), ophthalmic artery and central retinal artery occlusion, and polyneuritis cranialis were reported in different studies. Postmortem evaluation of COVID-19 patients detected no viral RNA in different anterior and posterior segments of the eyes. However, another study revealed a 21.4% positivity of the retinal biopsies of dead patients. The results of this study can help ophthalmologists to be vigilant when they see these findings in a suspected case of COVID-19. In addition, wearing face masks and protective goggles or eye shields are recommended, especially in high risk contacts.https://doi.org/10.18502/jovr.v16i2.9087coronaviruscovid-19manifestationsocularophthalmologic |
| spellingShingle | Amirhossein Roshanshad Mohammad Ali Ashraf Romina Roshanshad Ali Kharmandar Seyed Alireza Zomorodian Hossein Ashraf Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review Journal of Ophthalmic & Vision Research coronavirus covid-19 manifestations ocular ophthalmologic |
| title | Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review |
| title_full | Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review |
| title_fullStr | Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review |
| title_full_unstemmed | Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review |
| title_short | Ocular Manifestations of Patients with Coronavirus Disease 2019: A Comprehensive Review |
| title_sort | ocular manifestations of patients with coronavirus disease 2019 a comprehensive review |
| topic | coronavirus covid-19 manifestations ocular ophthalmologic |
| url | https://doi.org/10.18502/jovr.v16i2.9087 |
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