Sialylation regulates neutrophil transepithelial migration, CD11b/CD18 activation, and intestinal mucosal inflammatory function

Sialylation regulates neutrophil transepithelial migration, CD11b/CD18 activation, and intestinal mucosal inflammatory function

Polymorphonuclear neutrophils (PMNs) play a critical role in clearing invading microbes and promoting tissue repair following infection/injury. However, dysregulated PMN trafficking and associated tissue damage is pathognomonic of numerous inflammatory mucosal diseases. The final step in PMN influx...

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Detalles Bibliográficos
Autores principales: Veronica Azcutia, Matthias Kelm, Dylan Fink, Richard D. Cummings, Asma Nusrat, Charles A. Parkos, Jennifer C. Brazil
Formato: Artículo
Lenguaje:English
Publicado: American Society for Clinical investigation 2023-03-01
Colección:JCI Insight
Materias:
Immunology
Inflammation
Acceso en línea:https://doi.org/10.1172/jci.insight.167151

Internet

https://doi.org/10.1172/jci.insight.167151

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