The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets

The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets

Transmissible gastroenteritis virus (TGEV) is the etiologic agent of transmissible gastroenteritis in pigs, and the N-terminal domain of TGEV spike protein is generally recognized as both the virulence determinant and enteric tropism determinant. Here, we assembled a full-length infectious cDNA clon...

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Bibliographic Details
Main Authors: Gang Wang, Rui Liang, Ziwei Liu, Zhou Shen, Jiale Shi, Yuejun Shi, Feng Deng, Shaobo Xiao, Zhen F. Fu, Guiqing Peng
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
transmissible gastroenteritis virus
spike gene
enteric tropism
reverse genetics
CRISPR/Cas9
Online Access:https://www.mdpi.com/1999-4915/11/4/313

Internet

https://www.mdpi.com/1999-4915/11/4/313

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