SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin

Abstract Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by creating MSC specific SIRT1 knock‐out (MSCKO) mice. Ag...

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Bibliographic Details
Main Authors: Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:EMBO Molecular Medicine
Subjects:
bone
cartilage
fat
mesenchymal stem cells
sirtuin
Online Access:https://doi.org/10.1002/emmm.201201606

Internet

https://doi.org/10.1002/emmm.201201606

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