Immune checkpoint inhibitor myocarditis: a systematic case study

Myocarditis is a life-threatening complication of immune checkpoint inhibitor therapy. Over the past ten years, drugs in this group have been used in the treatment of a wide range of hematological diseases and solid tumors. With steadily growing life expectancy of cancer patients, problems associate...

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Main Authors: E. A. Kushnareva, O. M. Moiseeva
Format: Article
Language:Russian
Published: «FIRMA «SILICEA» LLC 2020-12-01
Series:Российский кардиологический журнал
Subjects:
Online Access:https://russjcardiol.elpub.ru/jour/article/view/3910
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author E. A. Kushnareva
O. M. Moiseeva
author_facet E. A. Kushnareva
O. M. Moiseeva
author_sort E. A. Kushnareva
collection DOAJ
description Myocarditis is a life-threatening complication of immune checkpoint inhibitor therapy. Over the past ten years, drugs in this group have been used in the treatment of a wide range of hematological diseases and solid tumors. With steadily growing life expectancy of cancer patients, problems associated with treatment complications are increasingly coming to the fore. Since 2016, publications have appeared on cases of autoimmune myocarditis during checkpoint inhibitor therapy (CIT), among which there are quite a few single-center retrospective and observational studies. At the same time, the problem of diagnosis and treatment of immune checkpoint inhibitor myocarditis remains unresolved.This paper presents a review on the problem of immune checkpoint inhibitor myocarditis, as well as the results of a systematic analysis of PubMed database publications.
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spelling doaj.art-d6fd057b2123412a93b9f4ec51596c052023-03-29T21:23:35Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-12-01251110.15829/29/1560-4071-2020-39102967Immune checkpoint inhibitor myocarditis: a systematic case studyE. A. Kushnareva0O. M. Moiseeva1Almazov National Medical Research CenterAlmazov National Medical Research CenterMyocarditis is a life-threatening complication of immune checkpoint inhibitor therapy. Over the past ten years, drugs in this group have been used in the treatment of a wide range of hematological diseases and solid tumors. With steadily growing life expectancy of cancer patients, problems associated with treatment complications are increasingly coming to the fore. Since 2016, publications have appeared on cases of autoimmune myocarditis during checkpoint inhibitor therapy (CIT), among which there are quite a few single-center retrospective and observational studies. At the same time, the problem of diagnosis and treatment of immune checkpoint inhibitor myocarditis remains unresolved.This paper presents a review on the problem of immune checkpoint inhibitor myocarditis, as well as the results of a systematic analysis of PubMed database publications.https://russjcardiol.elpub.ru/jour/article/view/3910checkpoint inhibitorsmyocarditiscardiotoxicity
spellingShingle E. A. Kushnareva
O. M. Moiseeva
Immune checkpoint inhibitor myocarditis: a systematic case study
Российский кардиологический журнал
checkpoint inhibitors
myocarditis
cardiotoxicity
title Immune checkpoint inhibitor myocarditis: a systematic case study
title_full Immune checkpoint inhibitor myocarditis: a systematic case study
title_fullStr Immune checkpoint inhibitor myocarditis: a systematic case study
title_full_unstemmed Immune checkpoint inhibitor myocarditis: a systematic case study
title_short Immune checkpoint inhibitor myocarditis: a systematic case study
title_sort immune checkpoint inhibitor myocarditis a systematic case study
topic checkpoint inhibitors
myocarditis
cardiotoxicity
url https://russjcardiol.elpub.ru/jour/article/view/3910
work_keys_str_mv AT eakushnareva immunecheckpointinhibitormyocarditisasystematiccasestudy
AT ommoiseeva immunecheckpointinhibitormyocarditisasystematiccasestudy