Behavioral Consequences of a Combination of Gad1 Haplodeficiency and Adolescent Exposure to an NMDA Receptor Antagonist in Long-Evans Rats

Behavioral Consequences of a Combination of Gad1 Haplodeficiency and Adolescent Exposure to an NMDA Receptor Antagonist in Long-Evans Rats

Glutamate decarboxylase 67-kDa isoform (GAD67), which is encoded by the GAD1 gene, is one of the key enzymes that produce GABA. The reduced expression of GAD67 has been linked to the pathophysiology of schizophrenia. Additionally, the excitatory glutamatergic system plays an important role in the de...

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Bibliographic Details
Main Authors: Kazuyuki Fujihara, Takumi Sato, Kazuya Higeta, Yoshiki Miyasaka, Tomoji Mashimo, Yuchio Yanagawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
γ-aminobutyric acid
GAD67
schizophrenia
MK-801 (dizocilpine)
CRISPR/ Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.646088/full

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