Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-<i>N</i>-Oxide Derivatives

Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-<i>N</i>-Oxide Derivatives

Infections caused by <i>Fasciola</i> species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in endemic areas. The current treatment is chemotherapeutic, tric...

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Bibliographic Details
Main Authors: Florencia Ferraro, Alicia Merlino, Jorge Gil, Hugo Cerecetto, Ileana Corvo, Mauricio Cabrera
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
<i>Fasciola hepatica</i>
cathepsin L
quinoxaline 1,4-di-<i>N</i>-oxides
small molecule inhibitors
molecular docking
Online Access:https://www.mdpi.com/1420-3049/24/13/2348

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