Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer
Carcinoembryonic antigen (CEA) is widely used to evaluate the effectiveness of treatment in patients with rectal cancer.The aim of the study was to investigate whether the CEA levels measured before and after neoadjuvant chemoradiotherapy (nCRT) can be used to predict pathological complete response...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2018-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/859 |
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| author | N. V. Severskaya D. V. Erygin Yu. V. Aleksandrov N. G. Minaeva N. Yu. Dvinskikh N. Yu. Novikov |
| author_facet | N. V. Severskaya D. V. Erygin Yu. V. Aleksandrov N. G. Minaeva N. Yu. Dvinskikh N. Yu. Novikov |
| author_sort | N. V. Severskaya |
| collection | DOAJ |
| description | Carcinoembryonic antigen (CEA) is widely used to evaluate the effectiveness of treatment in patients with rectal cancer.The aim of the study was to investigate whether the CEA levels measured before and after neoadjuvant chemoradiotherapy (nCRT) can be used to predict pathological complete response (pCR) in patients with locally advanced rectal cancer.Material and methods. 179 patients with locally advanced rectal cancer were treated with nCRT followed by surgical treatment. The serum CEA level was measured before and 610 weeks after the completion of nCRT. Preand post nCRT CEA levels were compared with pCR. The factors associated with pCR were studied.Results. pCR after nCRT was achieved in 12 % (22/179) patients. The incidence of pCR was higher in patients with normal (<5 ng/mL) pre-treatment CEA level (20 % vs 8 %, p=0.019). In patients with the elevated pre-treatment CEA level (> 5 ng/mL), there were no significant differences in the incidence of pCR between cases with normalization and without normalization of CEA level after treatment (p=0.08). The maximum likelihood of pCR determined by the ROC curve was <2.8 ng/mL with pre-treatment CEA (31 %) and <1.8 ng/mL with post-treatment CEA (23 %). Well differentiated tumors (G1) had higher likelihood of pCR (46%) in patients with low pre-treatment CEA (<2.8 ng/mL).Conclusion. Low CEA before and after nCRT is a predictor of pCR. Well differentiated tumors increase the probability of pCR after nCRT. |
| first_indexed | 2024-04-10T01:53:43Z |
| format | Article |
| id | doaj.art-d702722b7ee3467982524b2636ef771b |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:08:54Z |
| publishDate | 2018-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-d702722b7ee3467982524b2636ef771b2025-03-02T11:16:10ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-11-01175606610.21294/1814-4861-2018-17-5-60-66577Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancerN. V. Severskaya0D. V. Erygin1Yu. V. Aleksandrov2N. G. Minaeva3N. Yu. Dvinskikh4N. Yu. Novikov5National Medical Research Radiological Center of the Ministry of Health of the Russian FederationNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationCarcinoembryonic antigen (CEA) is widely used to evaluate the effectiveness of treatment in patients with rectal cancer.The aim of the study was to investigate whether the CEA levels measured before and after neoadjuvant chemoradiotherapy (nCRT) can be used to predict pathological complete response (pCR) in patients with locally advanced rectal cancer.Material and methods. 179 patients with locally advanced rectal cancer were treated with nCRT followed by surgical treatment. The serum CEA level was measured before and 610 weeks after the completion of nCRT. Preand post nCRT CEA levels were compared with pCR. The factors associated with pCR were studied.Results. pCR after nCRT was achieved in 12 % (22/179) patients. The incidence of pCR was higher in patients with normal (<5 ng/mL) pre-treatment CEA level (20 % vs 8 %, p=0.019). In patients with the elevated pre-treatment CEA level (> 5 ng/mL), there were no significant differences in the incidence of pCR between cases with normalization and without normalization of CEA level after treatment (p=0.08). The maximum likelihood of pCR determined by the ROC curve was <2.8 ng/mL with pre-treatment CEA (31 %) and <1.8 ng/mL with post-treatment CEA (23 %). Well differentiated tumors (G1) had higher likelihood of pCR (46%) in patients with low pre-treatment CEA (<2.8 ng/mL).Conclusion. Low CEA before and after nCRT is a predictor of pCR. Well differentiated tumors increase the probability of pCR after nCRT.https://www.siboncoj.ru/jour/article/view/859rectal cancerceatumor regression gradepathological complete responseneo-adjuvant chemoradiotherapy |
| spellingShingle | N. V. Severskaya D. V. Erygin Yu. V. Aleksandrov N. G. Minaeva N. Yu. Dvinskikh N. Yu. Novikov Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer Сибирский онкологический журнал rectal cancer cea tumor regression grade pathological complete response neo-adjuvant chemoradiotherapy |
| title | Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer |
| title_full | Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer |
| title_fullStr | Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer |
| title_full_unstemmed | Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer |
| title_short | Carcinoembryonic antigen BEFORE AND AFTER neoadjuvant chemoradiotherapy IN PREDICTION OF pathological complete response in patients with locally advanced rectal cancer |
| title_sort | carcinoembryonic antigen before and after neoadjuvant chemoradiotherapy in prediction of pathological complete response in patients with locally advanced rectal cancer |
| topic | rectal cancer cea tumor regression grade pathological complete response neo-adjuvant chemoradiotherapy |
| url | https://www.siboncoj.ru/jour/article/view/859 |
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