Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension

Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension

Pulmonary arterial hypertension (PAH) is a chronic cardiopulmonary disorder instigated by pulmonary vascular cell proliferation. Activation of Akt was previously reported to promote vascular remodeling. Also, the irreversible nitration of Y350 residue in Akt results in its activation. NitroAkt was i...

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Bibliographic Details
Main Authors: Mathews Valuparampil Varghese, Maki Niihori, Cody A Eccles, Sergey Kurdyukov, Joel James, Olga Rafikova, Ruslan Rafikov
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Antioxidants
Subjects:
pulmonary arterial hypertension
metabolism
warburg effect
anaplerosis
nitroxide-conjugated peptide
akt
Online Access:https://www.mdpi.com/2076-3921/9/2/104

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