The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro

The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro

Abstract Background Lipopolysaccharide (LPS) is one of the main constituents of the cell wall of gram-negative bacteria. As an endotoxin, LPS induces neuroinflammation, which is associated with the blood-brain barrier impairment. Lactate is a metabolite with some significant physiological functions...

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Bibliographic Details
Main Authors: Elizaveta B. Boitsova, Andrey V. Morgun, Elena D. Osipova, Elena A. Pozhilenkova, Galina P. Martinova, Olga V. Frolova, Raissa Ya Olovannikova, Abolghasem Tohidpour, Yana V. Gorina, Yulia A. Panina, Alla B. Salmina
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Lipopolysaccharide
Neuroinflammation
Blood-brain barrier
Lactate
Online Access:http://link.springer.com/article/10.1186/s12974-018-1233-2

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