Characterization of age-related immune features after autologous NK cell infusion: Protocol for an open-label and randomized controlled trial

Characterization of age-related immune features after autologous NK cell infusion: Protocol for an open-label and randomized controlled trial

BackgroundAging is usually accompanied by functional declines of the immune system, especially in T-cell responses. However, little is known about ways to alleviate this.MethodsHere, 37 middle-aged healthy participants were recruited, among which 32 were intravenously administrated with expanded NK...

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Main Authors: Xiaofeng Tang, Biaolong Deng, Aiping Zang, Xiaowen He, Ye Zhou, Daimeng Wang, Dan Li, Xueyu Dai, Jieqiong Chen, Xuhua Zhang, Ye Liu, Yonghua Xu, Jingjing Chen, Weijie Zheng, Luding Zhang, Constance Gao, Huanfeng Yang, Bin Li, Xueqi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
aging
T-cell senescence
T-cell exhaustion
natural killer cells
SASP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.940577/full

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