Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer
Nasopharyngeal cancer is the most common cancer of head and neck cancer in Vietnam. The infection of Epstein-Barr virus (EBV) has been reported to be the cause of nasopharyngeal tumorigenesis. In Vietnam, the studies relevant to EBV, especially the molecular of EBV, are still limited. In the current...
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| Format: | Article |
| Language: | English |
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HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE
2019-09-01
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| Series: | Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ |
| Subjects: | |
| Online Access: | https://journalofscience.ou.edu.vn/index.php/tech-vi/article/view/437 |
| _version_ | 1828793985254031360 |
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| author | Nguyễn Hoàng Anh Tuấn Thiều Hồng Huệ Lao Đức Thuận Lê Huyền Ái Thuý |
| author_facet | Nguyễn Hoàng Anh Tuấn Thiều Hồng Huệ Lao Đức Thuận Lê Huyền Ái Thuý |
| author_sort | Nguyễn Hoàng Anh Tuấn |
| collection | DOAJ |
| description | Nasopharyngeal cancer is the most common cancer of head and neck cancer in Vietnam. The infection of Epstein-Barr virus (EBV) has been reported to be the cause of nasopharyngeal tumorigenesis. In Vietnam, the studies relevant to EBV, especially the molecular of EBV, are still limited. In the current study, the databases were systematically analyzed to establish the scientific basis for the molecular of EBV which could be applied in further studies. This study was focused on the analysis of three families of EBV genes, included EBNAs, LMPs and EBER based on a meta-analysis. As the result, most studies were focused on the detection of EBNA-1, LMP-1 and EBER. The frequencies of EBNA-1, LMP-1 and EBER were 92.12%; 78.93% and 88.12%, respectively. Moreover, a random effect model was applied to calculate the OR and RR: EBNA-1: RR=20.10; OR= 332.75; LMP-1: RR=3.63; OR=17.9 and EBER: RR=5.4; OR=46.11. Those results indicated that the presence of EBV genes was significantly associated with nasopharyngeal carcinoma. According to the method, PCR was the common method used for the detection of the EBV genes’ presence. Moreover, the nasopharyngeal biopsy was the main source of samples enrolled in nasopharyngeal cancer studied. In summary, we successfully conducted the molecular database about the presence of EBV genes, included the frequency, OR and RR value to be the scientific database for further studies relevant to nasopharyngeal cancer in the Vietnamese population. |
| first_indexed | 2024-12-12T03:36:12Z |
| format | Article |
| id | doaj.art-d7045bd3e373432dba8b0a1fbe96a7ba |
| institution | Directory Open Access Journal |
| issn | 2734-9322 2734-9594 |
| language | English |
| last_indexed | 2024-12-12T03:36:12Z |
| publishDate | 2019-09-01 |
| publisher | HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE |
| record_format | Article |
| series | Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ |
| spelling | doaj.art-d7045bd3e373432dba8b0a1fbe96a7ba2022-12-22T00:39:47ZengHO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCETạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ2734-93222734-95942019-09-011419510710.46223/HCMCOUJS.tech.vi.14.1.437.2019381Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancerNguyễn Hoàng Anh Tuấn0Thiều Hồng Huệ1Lao Đức Thuận2Lê Huyền Ái Thuý3Trường Đại học Khoa học Tự Nhiên, Thành phố Hồ Chí MinhTrường Đại học Mở Thành phố Hồ Chí MinhTrường Đại học Mở Thành phố Hồ Chí MinhTrường Đại học Mở Thành phố Hồ Chí MinhNasopharyngeal cancer is the most common cancer of head and neck cancer in Vietnam. The infection of Epstein-Barr virus (EBV) has been reported to be the cause of nasopharyngeal tumorigenesis. In Vietnam, the studies relevant to EBV, especially the molecular of EBV, are still limited. In the current study, the databases were systematically analyzed to establish the scientific basis for the molecular of EBV which could be applied in further studies. This study was focused on the analysis of three families of EBV genes, included EBNAs, LMPs and EBER based on a meta-analysis. As the result, most studies were focused on the detection of EBNA-1, LMP-1 and EBER. The frequencies of EBNA-1, LMP-1 and EBER were 92.12%; 78.93% and 88.12%, respectively. Moreover, a random effect model was applied to calculate the OR and RR: EBNA-1: RR=20.10; OR= 332.75; LMP-1: RR=3.63; OR=17.9 and EBER: RR=5.4; OR=46.11. Those results indicated that the presence of EBV genes was significantly associated with nasopharyngeal carcinoma. According to the method, PCR was the common method used for the detection of the EBV genes’ presence. Moreover, the nasopharyngeal biopsy was the main source of samples enrolled in nasopharyngeal cancer studied. In summary, we successfully conducted the molecular database about the presence of EBV genes, included the frequency, OR and RR value to be the scientific database for further studies relevant to nasopharyngeal cancer in the Vietnamese population.https://journalofscience.ou.edu.vn/index.php/tech-vi/article/view/437epstein-barr virusphân tích tổng hợpung thư vòm họngviệt namepstein-barr virusmeta-analysisnasopharyngeal carcinomavietnam |
| spellingShingle | Nguyễn Hoàng Anh Tuấn Thiều Hồng Huệ Lao Đức Thuận Lê Huyền Ái Thuý Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ epstein-barr virus phân tích tổng hợp ung thư vòm họng việt nam epstein-barr virus meta-analysis nasopharyngeal carcinoma vietnam |
| title | Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer |
| title_full | Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer |
| title_fullStr | Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer |
| title_full_unstemmed | Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer |
| title_short | Meta-analysis: Epstein-Barr Virus genes - EBNAs, LMPs, and EBERs one of the major causes of nasopharyngeal cancer |
| title_sort | meta analysis epstein barr virus genes ebnas lmps and ebers one of the major causes of nasopharyngeal cancer |
| topic | epstein-barr virus phân tích tổng hợp ung thư vòm họng việt nam epstein-barr virus meta-analysis nasopharyngeal carcinoma vietnam |
| url | https://journalofscience.ou.edu.vn/index.php/tech-vi/article/view/437 |
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