X chromosome reactivation initiates in nascent primordial germ cells in mice.
During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1950944?pdf=render |
| _version_ | 1818315758645542912 |
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| author | Michihiko Sugimoto Kuniya Abe |
| author_facet | Michihiko Sugimoto Kuniya Abe |
| author_sort | Michihiko Sugimoto |
| collection | DOAJ |
| description | During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps. |
| first_indexed | 2024-12-13T09:10:38Z |
| format | Article |
| id | doaj.art-d7060d92298443338d11ffb4ccbdda4d |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-13T09:10:38Z |
| publishDate | 2007-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-d7060d92298443338d11ffb4ccbdda4d2022-12-21T23:52:56ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042007-07-0137e11610.1371/journal.pgen.0030116X chromosome reactivation initiates in nascent primordial germ cells in mice.Michihiko SugimotoKuniya AbeDuring primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps.http://europepmc.org/articles/PMC1950944?pdf=render |
| spellingShingle | Michihiko Sugimoto Kuniya Abe X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genetics |
| title | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| title_full | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| title_fullStr | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| title_full_unstemmed | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| title_short | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| title_sort | x chromosome reactivation initiates in nascent primordial germ cells in mice |
| url | http://europepmc.org/articles/PMC1950944?pdf=render |
| work_keys_str_mv | AT michihikosugimoto xchromosomereactivationinitiatesinnascentprimordialgermcellsinmice AT kuniyaabe xchromosomereactivationinitiatesinnascentprimordialgermcellsinmice |