Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method
This research involves an indirect Fluorophotometric method for the determination of microgram amount of oxymetazoline hydrochloride in the concentration range 0.1-5.0 g/ml. The method is based on the oxidation of the drug by cerium sulphate solution which is acidic medium where Ce IV is reduced to...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2017-03-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/137 |
| _version_ | 1811308162767126528 |
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| author | Mohammed S. Saleem Ikram K. Othman |
| author_facet | Mohammed S. Saleem Ikram K. Othman |
| author_sort | Mohammed S. Saleem |
| collection | DOAJ |
| description |
This research involves an indirect Fluorophotometric method for the determination of microgram amount of oxymetazoline hydrochloride in the concentration range 0.1-5.0 g/ml. The method is based on the oxidation of the drug by cerium sulphate solution which is acidic medium where Ce IV is reduced to Ce III which can be excited at 259 nm to give an emitted light at 377 nm which is directly proportional to the concentration of Ce III which is equivalent to Ce IV that is needed to oxidize the studied drug. The average recovery of the method is 100.19% and relative standard deviation (RSD) < 0.37% . The method have been successfully applied to the determination of the studied drug in its pure and pharmaceutical preparations and it was found that the results obtained are agree favorably with certified values of pharmaceutical preparations and also with result obtained by standard addition method.
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| first_indexed | 2024-04-13T09:17:03Z |
| format | Article |
| id | doaj.art-d707db4c24b84a309e4d284a289d4791 |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-04-13T09:17:03Z |
| publishDate | 2017-03-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-d707db4c24b84a309e4d284a289d47912022-12-22T02:52:42ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072017-03-01292Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric MethodMohammed S. SaleemIkram K. Othman This research involves an indirect Fluorophotometric method for the determination of microgram amount of oxymetazoline hydrochloride in the concentration range 0.1-5.0 g/ml. The method is based on the oxidation of the drug by cerium sulphate solution which is acidic medium where Ce IV is reduced to Ce III which can be excited at 259 nm to give an emitted light at 377 nm which is directly proportional to the concentration of Ce III which is equivalent to Ce IV that is needed to oxidize the studied drug. The average recovery of the method is 100.19% and relative standard deviation (RSD) < 0.37% . The method have been successfully applied to the determination of the studied drug in its pure and pharmaceutical preparations and it was found that the results obtained are agree favorably with certified values of pharmaceutical preparations and also with result obtained by standard addition method. https://jih.uobaghdad.edu.iq/index.php/j/article/view/137. (IV)Fluorophotometric, Oxymetazoline hydrochloride, Cerium sulphate |
| spellingShingle | Mohammed S. Saleem Ikram K. Othman Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method Ibn Al-Haitham Journal for Pure and Applied Sciences . (IV)Fluorophotometric, Oxymetazoline hydrochloride, Cerium sulphate |
| title | Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method |
| title_full | Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method |
| title_fullStr | Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method |
| title_full_unstemmed | Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method |
| title_short | Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pharmaceutical Formulation Using Fluorophotometric Method |
| title_sort | indirect spectrophotometric determination of oxymetazoline hydrochloride in pharmaceutical formulation using fluorophotometric method |
| topic | . (IV)Fluorophotometric, Oxymetazoline hydrochloride, Cerium sulphate |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/137 |
| work_keys_str_mv | AT mohammedssaleem indirectspectrophotometricdeterminationofoxymetazolinehydrochlorideinpharmaceuticalformulationusingfluorophotometricmethod AT ikramkothman indirectspectrophotometricdeterminationofoxymetazolinehydrochlorideinpharmaceuticalformulationusingfluorophotometricmethod |