Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1.

Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1.

PGT121 is a broadly neutralizing antibody in clinical development for the treatment and prevention of HIV-1 infection via passive administration. PGT121 targets the HIV-1 V3-glycan and demonstrated potent antiviral activity in a phase I clinical trial. Resistance to PGT121 monotherapy rapidly occurr...

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Bibliographic Details
Main Authors:	Tyler Cassidy, Kathryn E Stephenson, Dan H Barouch, Alan S Perelson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-03-01
Series:	PLoS Computational Biology
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011518&type=printable

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