Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity
The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/3/144 |
| _version_ | 1797471453508009984 |
|---|---|
| author | Samah Hamed Almurisi Khater AL-Japairai Farhan Alshammari Fawaz Alheibshy Rana M.F. Sammour Abd Almonem Doolaanea |
| author_facet | Samah Hamed Almurisi Khater AL-Japairai Farhan Alshammari Fawaz Alheibshy Rana M.F. Sammour Abd Almonem Doolaanea |
| author_sort | Samah Hamed Almurisi |
| collection | DOAJ |
| description | The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol’s stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability. |
| first_indexed | 2024-03-09T19:49:39Z |
| format | Article |
| id | doaj.art-d70e878a41834a2fa02426344936f6dd |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T19:49:39Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d70e878a41834a2fa02426344936f6dd2023-11-24T01:16:15ZengMDPI AGGels2310-28612022-02-018314410.3390/gels8030144Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and HumiditySamah Hamed Almurisi0Khater AL-Japairai1Farhan Alshammari2Fawaz Alheibshy3Rana M.F. Sammour4Abd Almonem Doolaanea5Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25200, MalaysiaDepartment of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, MalaysiaDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi ArabiaPharmaceutics Department, Dubai Pharmacy College for Girls, Dubai 19099, United Arab EmiratesDepartment of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25200, MalaysiaThe stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol’s stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability.https://www.mdpi.com/2310-2861/8/3/144paracetamolstabilitypackagingenvironmental conditionsshelf life |
| spellingShingle | Samah Hamed Almurisi Khater AL-Japairai Farhan Alshammari Fawaz Alheibshy Rana M.F. Sammour Abd Almonem Doolaanea Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity Gels paracetamol stability packaging environmental conditions shelf life |
| title | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity |
| title_full | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity |
| title_fullStr | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity |
| title_full_unstemmed | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity |
| title_short | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity |
| title_sort | stability of paracetamol instant jelly for reconstitution impact of packaging temperature and humidity |
| topic | paracetamol stability packaging environmental conditions shelf life |
| url | https://www.mdpi.com/2310-2861/8/3/144 |
| work_keys_str_mv | AT samahhamedalmurisi stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity AT khateraljapairai stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity AT farhanalshammari stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity AT fawazalheibshy stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity AT ranamfsammour stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity AT abdalmonemdoolaanea stabilityofparacetamolinstantjellyforreconstitutionimpactofpackagingtemperatureandhumidity |