Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study
Background People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV‐associated LVDD may reflect both cardiomyocyte and systemic metabolic derangements, but the underlying pathways remain unclear. Methods and Results To explore such pathway...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013522 |
| _version_ | 1827992580596432896 |
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| author | Claudio A. Bravo Simin Hua Amy Deik Jason Lazar David B. Hanna Justin Scott Jin Choul Chai Robert C. Kaplan Kathryn Anastos Octavio A. Robles Clary B. Clish Jorge R. Kizer Qibin Qi |
| author_facet | Claudio A. Bravo Simin Hua Amy Deik Jason Lazar David B. Hanna Justin Scott Jin Choul Chai Robert C. Kaplan Kathryn Anastos Octavio A. Robles Clary B. Clish Jorge R. Kizer Qibin Qi |
| author_sort | Claudio A. Bravo |
| collection | DOAJ |
| description | Background People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV‐associated LVDD may reflect both cardiomyocyte and systemic metabolic derangements, but the underlying pathways remain unclear. Methods and Results To explore such pathways, we conducted a pilot study in the Bronx and Brooklyn sites of the WIHS (Women's Interagency HIV Study) who participated in concurrent, but separate, metabolomics and echocardiographic ancillary studies. Liquid chromatography tandem mass spectrometry–based metabolomic profiling was performed on plasma samples from 125 HIV‐infected (43 with LVDD) and 35 HIV‐uninfected women (9 with LVDD). Partial least squares discriminant analysis identified polar metabolites and lipids in the glycerophospholipid‐metabolism and fatty‐acid‐oxidation pathways associated with LVDD. After multivariable adjustment, LVDD was significantly associated with higher concentrations of diacylglycerol 30:0 (odds ratio [OR], 1.60, 95% CI [1.01–2.55]); triacylglycerols 46:0 (OR 1.60 [1.04–2.48]), 48:0 (OR 1.63 [1.04–2.54]), 48:1 (OR 1.62 [1.01–2.60]), and 50:0 (OR 1.61 [1.02–2.53]); acylcarnitine C7 (OR 1.88 [1.21–2.92]), C9 (OR 1.99 [1.27–3.13]), and C16 (OR 1.80 [1.13–2.87]); as well as lower concentrations of phosphocholine (OR 0.59 [0.38–0.91]). There was no evidence of effect modification of these relationships by HIV status. Conclusions In this pilot study, women with or at risk of HIV with LVDD showed alterations in plasma metabolites in the glycerophospholipid‐metabolism and fatty‐acid‐oxidation pathways. Although these findings require replication, they suggest that improved understanding of metabolic perturbations and their potential modification could offer new approaches to prevent cardiac dysfunction in this high‐risk group. |
| first_indexed | 2024-04-10T04:06:18Z |
| format | Article |
| id | doaj.art-d70f232d2d9c4143a18ec1e3f93e9d29 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T04:06:18Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-d70f232d2d9c4143a18ec1e3f93e9d292023-03-13T05:25:33ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-02-019410.1161/JAHA.119.013522Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV StudyClaudio A. Bravo0Simin Hua1Amy Deik2Jason Lazar3David B. Hanna4Justin Scott5Jin Choul Chai6Robert C. Kaplan7Kathryn Anastos8Octavio A. Robles9Clary B. Clish10Jorge R. Kizer11Qibin Qi12Division of Cardiology Department of Medicine Columbia University Medical Center New York NYDepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYMetabolomics Platform Broad Institute of MIT and Harvard Cambridge MADivision of Cardiovascular Medicine State University of New York Downstate Medical Center Brooklyn NYDepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYMetabolomics Platform Broad Institute of MIT and Harvard Cambridge MADepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYDepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYDepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYDepartment of Biologic Sciences Universidad de Chile Santiago ChileMetabolomics Platform Broad Institute of MIT and Harvard Cambridge MADivision of Cardiology San Francisco Veterans Affairs Health Care System University of California San Francisco San Francisco CADepartment of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NYBackground People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV‐associated LVDD may reflect both cardiomyocyte and systemic metabolic derangements, but the underlying pathways remain unclear. Methods and Results To explore such pathways, we conducted a pilot study in the Bronx and Brooklyn sites of the WIHS (Women's Interagency HIV Study) who participated in concurrent, but separate, metabolomics and echocardiographic ancillary studies. Liquid chromatography tandem mass spectrometry–based metabolomic profiling was performed on plasma samples from 125 HIV‐infected (43 with LVDD) and 35 HIV‐uninfected women (9 with LVDD). Partial least squares discriminant analysis identified polar metabolites and lipids in the glycerophospholipid‐metabolism and fatty‐acid‐oxidation pathways associated with LVDD. After multivariable adjustment, LVDD was significantly associated with higher concentrations of diacylglycerol 30:0 (odds ratio [OR], 1.60, 95% CI [1.01–2.55]); triacylglycerols 46:0 (OR 1.60 [1.04–2.48]), 48:0 (OR 1.63 [1.04–2.54]), 48:1 (OR 1.62 [1.01–2.60]), and 50:0 (OR 1.61 [1.02–2.53]); acylcarnitine C7 (OR 1.88 [1.21–2.92]), C9 (OR 1.99 [1.27–3.13]), and C16 (OR 1.80 [1.13–2.87]); as well as lower concentrations of phosphocholine (OR 0.59 [0.38–0.91]). There was no evidence of effect modification of these relationships by HIV status. Conclusions In this pilot study, women with or at risk of HIV with LVDD showed alterations in plasma metabolites in the glycerophospholipid‐metabolism and fatty‐acid‐oxidation pathways. Although these findings require replication, they suggest that improved understanding of metabolic perturbations and their potential modification could offer new approaches to prevent cardiac dysfunction in this high‐risk group.https://www.ahajournals.org/doi/10.1161/JAHA.119.013522heart failureHIVleft ventricular diastolic dysfunctionmetabolomics |
| spellingShingle | Claudio A. Bravo Simin Hua Amy Deik Jason Lazar David B. Hanna Justin Scott Jin Choul Chai Robert C. Kaplan Kathryn Anastos Octavio A. Robles Clary B. Clish Jorge R. Kizer Qibin Qi Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease heart failure HIV left ventricular diastolic dysfunction metabolomics |
| title | Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study |
| title_full | Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study |
| title_fullStr | Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study |
| title_full_unstemmed | Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study |
| title_short | Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study |
| title_sort | metabolomic profiling of left ventricular diastolic dysfunction in women with or at risk for hiv infection the women s interagency hiv study |
| topic | heart failure HIV left ventricular diastolic dysfunction metabolomics |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013522 |
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