Pulmonary Thromboembolism following Russell’s Viper Bites

Snakebite envenoming and its resulting complications are serious threats to the health of vulnerable people living in rural areas of developing countries. The knowledge of the heterogeneity of symptoms associated with snakebite envenoming and their management strategies is vital to treat such life-t...

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Hauptverfasser: Subramanian Senthilkumaran, Sasikumar Sampath, José R. Almeida, Jarred Williams, Harry F. Williams, Ketan Patel, Ponniah Thirumalaikolundusubramanian, Sakthivel Vaiyapuri
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2024-05-01
Schriftenreihe:Toxins
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Online Zugang:https://www.mdpi.com/2072-6651/16/5/222
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author Subramanian Senthilkumaran
Sasikumar Sampath
José R. Almeida
Jarred Williams
Harry F. Williams
Ketan Patel
Ponniah Thirumalaikolundusubramanian
Sakthivel Vaiyapuri
author_facet Subramanian Senthilkumaran
Sasikumar Sampath
José R. Almeida
Jarred Williams
Harry F. Williams
Ketan Patel
Ponniah Thirumalaikolundusubramanian
Sakthivel Vaiyapuri
author_sort Subramanian Senthilkumaran
collection DOAJ
description Snakebite envenoming and its resulting complications are serious threats to the health of vulnerable people living in rural areas of developing countries. The knowledge of the heterogeneity of symptoms associated with snakebite envenoming and their management strategies is vital to treat such life-threatening complications to save lives. Russell’s viper envenomation induces a diverse range of clinical manifestations from commonly recognised haemotoxic and local effects to several rare conditions that are often not reported. The lack of awareness about these unusual manifestations can affect prompt diagnosis, appropriate therapeutic approaches, and positive outcomes for patients. Here, we report pulmonary thromboembolism that developed in three patients following Russell’s viper envenomation and demonstrate their common clinical features and diagnostic and therapeutic approaches used. All patients showed clinical signs of local (oedema) and systemic (blood coagulation disturbances) envenomation, which were treated using polyvalent antivenom. They exhibited elevated heart rates, breathlessness, and reduced oxygen saturation, which are non-specific but core parameters in the diagnosis of pulmonary embolism. The recognition of pulmonary embolism was also achieved by an electrocardiogram, which showed sinus tachycardia and computed tomography and echocardiogram scans further confirmed this condition. Anti-coagulant treatment using low-molecular-weight heparin offered clinical benefits in these patients. In summary, this report reinforces the broad spectrum of previously unreported consequences of Russell’s viper envenomation. The constant updating of healthcare professionals and the dissemination of major lessons learned in the clinical management of snakebite envenoming through scientific documentation and educational programs are necessary to mitigate the adverse impacts of venomous snakebites in vulnerable communities.
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spelling doaj.art-d70f39d9cc1f4ed6b27a8b10c6575d352024-05-24T13:41:50ZengMDPI AGToxins2072-66512024-05-0116522210.3390/toxins16050222Pulmonary Thromboembolism following Russell’s Viper BitesSubramanian Senthilkumaran0Sasikumar Sampath1José R. Almeida2Jarred Williams3Harry F. Williams4Ketan Patel5Ponniah Thirumalaikolundusubramanian6Sakthivel Vaiyapuri7Manian Medical Centre, Erode 638001, IndiaPrimary Health Care Corporation, Doha 26555, QatarSchool of Pharmacy, University of Reading, Reading RG6 6UB, UKSchool of Pharmacy, University of Reading, Reading RG6 6UB, UKToxiven Biotech Private Limited, Coimbatore 641042, IndiaSchool of Biological Sciences, University of Reading, Reading RG6 6UB, UKThe Tamil Nadu Dr M.G.R Medical University, Chennai 600032, IndiaSchool of Pharmacy, University of Reading, Reading RG6 6UB, UKSnakebite envenoming and its resulting complications are serious threats to the health of vulnerable people living in rural areas of developing countries. The knowledge of the heterogeneity of symptoms associated with snakebite envenoming and their management strategies is vital to treat such life-threatening complications to save lives. Russell’s viper envenomation induces a diverse range of clinical manifestations from commonly recognised haemotoxic and local effects to several rare conditions that are often not reported. The lack of awareness about these unusual manifestations can affect prompt diagnosis, appropriate therapeutic approaches, and positive outcomes for patients. Here, we report pulmonary thromboembolism that developed in three patients following Russell’s viper envenomation and demonstrate their common clinical features and diagnostic and therapeutic approaches used. All patients showed clinical signs of local (oedema) and systemic (blood coagulation disturbances) envenomation, which were treated using polyvalent antivenom. They exhibited elevated heart rates, breathlessness, and reduced oxygen saturation, which are non-specific but core parameters in the diagnosis of pulmonary embolism. The recognition of pulmonary embolism was also achieved by an electrocardiogram, which showed sinus tachycardia and computed tomography and echocardiogram scans further confirmed this condition. Anti-coagulant treatment using low-molecular-weight heparin offered clinical benefits in these patients. In summary, this report reinforces the broad spectrum of previously unreported consequences of Russell’s viper envenomation. The constant updating of healthcare professionals and the dissemination of major lessons learned in the clinical management of snakebite envenoming through scientific documentation and educational programs are necessary to mitigate the adverse impacts of venomous snakebites in vulnerable communities.https://www.mdpi.com/2072-6651/16/5/222snakebite envenomingpulmonary embolismRussell’s viperD-dimersCT pulmonary angiographyechocardiogram
spellingShingle Subramanian Senthilkumaran
Sasikumar Sampath
José R. Almeida
Jarred Williams
Harry F. Williams
Ketan Patel
Ponniah Thirumalaikolundusubramanian
Sakthivel Vaiyapuri
Pulmonary Thromboembolism following Russell’s Viper Bites
Toxins
snakebite envenoming
pulmonary embolism
Russell’s viper
D-dimers
CT pulmonary angiography
echocardiogram
title Pulmonary Thromboembolism following Russell’s Viper Bites
title_full Pulmonary Thromboembolism following Russell’s Viper Bites
title_fullStr Pulmonary Thromboembolism following Russell’s Viper Bites
title_full_unstemmed Pulmonary Thromboembolism following Russell’s Viper Bites
title_short Pulmonary Thromboembolism following Russell’s Viper Bites
title_sort pulmonary thromboembolism following russell s viper bites
topic snakebite envenoming
pulmonary embolism
Russell’s viper
D-dimers
CT pulmonary angiography
echocardiogram
url https://www.mdpi.com/2072-6651/16/5/222
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