Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis
BackgroundThis meta-analysis was conducted to assess the survival benefits of repeat hepatectomy (RH) and thermal ablation therapy (TAT) in managing recurrent hepatocellular carcinoma (HCC).MethodsA comprehensive search was conducted in the PubMed, SinoMed, Embase, Cochrane Library, Medline, and Web...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1370390/full |
| _version_ | 1797238500506992640 |
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| author | Renhua Dong Ting Zhang Wenwu Wan Hao Zhang |
| author_facet | Renhua Dong Ting Zhang Wenwu Wan Hao Zhang |
| author_sort | Renhua Dong |
| collection | DOAJ |
| description | BackgroundThis meta-analysis was conducted to assess the survival benefits of repeat hepatectomy (RH) and thermal ablation therapy (TAT) in managing recurrent hepatocellular carcinoma (HCC).MethodsA comprehensive search was conducted in the PubMed, SinoMed, Embase, Cochrane Library, Medline, and Web of Science databases using relevant keywords to identify all studies published on this specific topic. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were estimated using a fixed-effects model.ResultsThis meta-analysis included a total of 21 studies, comprising 2580 patients with recurrent HCC, among whom 1189 underwent RH and 1394 underwent TAT. Meta-analysis results demonstrated that the RH group exhibited superior overall survival (OS) (HR=0.85, 95%CI 0.76∼0.95, P=0.004) and recurrence-free survival (RFS) (HR=0.79, 95%CI 0.7∼0.9, P<0.01) compared to the TAT group. Regarding postoperative complications, the TAT group experienced fewer complications than the RH group (OR=3.23, 95%CI 1.48∼7.07, P=0.003), while no significant difference in perioperative mortality was observed between the two groups (OR=2.11, 95%CI 0.54∼8.19, P=0.28).ConclusionThe present study demonstrates that, in comparison to TAT, RH may confer superior survival benefits for patients with recurrent HCC. |
| first_indexed | 2024-04-24T17:36:38Z |
| format | Article |
| id | doaj.art-d70fdb1c21c7430aadb3a88a261778b5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T17:36:38Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d70fdb1c21c7430aadb3a88a261778b52024-03-28T04:37:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13703901370390Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysisRenhua Dong0Ting Zhang1Wenwu Wan2Hao Zhang3Department of Hepatobiliary and Pancreatic Surgery, Meishan People’s Hospital, Meishan, Sichuan, ChinaDepartment of Gastroenterology, Meishan People’s Hospital, Meishan, Sichuan, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Meishan People’s Hospital, Meishan, Sichuan, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Meishan People’s Hospital, Meishan, Sichuan, ChinaBackgroundThis meta-analysis was conducted to assess the survival benefits of repeat hepatectomy (RH) and thermal ablation therapy (TAT) in managing recurrent hepatocellular carcinoma (HCC).MethodsA comprehensive search was conducted in the PubMed, SinoMed, Embase, Cochrane Library, Medline, and Web of Science databases using relevant keywords to identify all studies published on this specific topic. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were estimated using a fixed-effects model.ResultsThis meta-analysis included a total of 21 studies, comprising 2580 patients with recurrent HCC, among whom 1189 underwent RH and 1394 underwent TAT. Meta-analysis results demonstrated that the RH group exhibited superior overall survival (OS) (HR=0.85, 95%CI 0.76∼0.95, P=0.004) and recurrence-free survival (RFS) (HR=0.79, 95%CI 0.7∼0.9, P<0.01) compared to the TAT group. Regarding postoperative complications, the TAT group experienced fewer complications than the RH group (OR=3.23, 95%CI 1.48∼7.07, P=0.003), while no significant difference in perioperative mortality was observed between the two groups (OR=2.11, 95%CI 0.54∼8.19, P=0.28).ConclusionThe present study demonstrates that, in comparison to TAT, RH may confer superior survival benefits for patients with recurrent HCC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1370390/fullrepeat hepatectomythermal ablation therapymeta-analysisrecurrent hepatocellular carcinomasystematic review |
| spellingShingle | Renhua Dong Ting Zhang Wenwu Wan Hao Zhang Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis Frontiers in Oncology repeat hepatectomy thermal ablation therapy meta-analysis recurrent hepatocellular carcinoma systematic review |
| title | Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis |
| title_full | Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis |
| title_fullStr | Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis |
| title_full_unstemmed | Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis |
| title_short | Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis |
| title_sort | repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma a systematic review and meta analysis |
| topic | repeat hepatectomy thermal ablation therapy meta-analysis recurrent hepatocellular carcinoma systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1370390/full |
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