Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorders (PND) are a cognitive impairment that occurs after anesthesia, especially in elderly patients and significantly affects their quality of life. The hippocampus, as a critical region for cognitive function and an important location in PND research, has recently a...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-02-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302038 |
| _version_ | 1797291526344146944 |
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| author | Feng-Nian Jia An-Ran Chen Hui-Hua Li Cui-Cui Yu |
| author_facet | Feng-Nian Jia An-Ran Chen Hui-Hua Li Cui-Cui Yu |
| author_sort | Feng-Nian Jia |
| collection | DOAJ |
| description | Perioperative neurocognitive disorders (PND) are a cognitive impairment that occurs after anesthesia, especially in elderly patients and significantly affects their quality of life. The hippocampus, as a critical region for cognitive function and an important location in PND research, has recently attracted increasing attention. However, in the hippocampus the impact of anesthesia and its underlying mechanisms remain unclear. This review focuses on investigation of the effects of anesthesia on the hippocampal dopamine (DA) system and explores its potential association with PND. Through comprehensive review of existing studies, it was found that anesthesia affects the hippocampus through various pathways involved in metabolism, synaptic plasticity and oxygenation. Anesthesia may also influence the DA neurotransmitter system in the brain which plays a role in emotions, rewards, learning and memory functions. Specifically, anesthesia may participate in the pathogenesis of PND by affecting the DA system within the hippocampus. Future studies should explore the molecular mechanisms of these effects through techniques such as neuroimaging to study real-time effects to improve animal models to better simulate clinical observations. For clinical application, it is recommended that physicians exercise caution when selecting and managing anesthetic drugs by adopting comprehensive cognitive assessment methods to reduce post-anesthesia cognitive risk. Overall, this review provides a better understanding of the relationship between the hippocampal DA system and perioperative neurocognitive function and provides valuable guidance for prevention and treatment strategies for PND. |
| first_indexed | 2024-03-07T19:38:04Z |
| format | Article |
| id | doaj.art-d71261eec60e4bc9bbc9de53ca394c27 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-07T19:38:04Z |
| publishDate | 2024-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-d71261eec60e4bc9bbc9de53ca394c272024-02-29T08:00:15ZengIMR PressJournal of Integrative Neuroscience0219-63522024-02-012323810.31083/j.jin2302038S0219-6352(23)00662-9Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive DisordersFeng-Nian Jia0An-Ran Chen1Hui-Hua Li2Cui-Cui Yu3The Second School of Clinical Medical of Binzhou Medical University, 264003 Yantai, Shandong, ChinaDepartment of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaDepartment of Psychiatry, Zhenjiang Mental Health Center, The Fifth People’s Hospital of Zhenjiang City, 212000 Zhenjiang, Jiangsu, ChinaDepartment of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000 Yantai, Shandong, ChinaPerioperative neurocognitive disorders (PND) are a cognitive impairment that occurs after anesthesia, especially in elderly patients and significantly affects their quality of life. The hippocampus, as a critical region for cognitive function and an important location in PND research, has recently attracted increasing attention. However, in the hippocampus the impact of anesthesia and its underlying mechanisms remain unclear. This review focuses on investigation of the effects of anesthesia on the hippocampal dopamine (DA) system and explores its potential association with PND. Through comprehensive review of existing studies, it was found that anesthesia affects the hippocampus through various pathways involved in metabolism, synaptic plasticity and oxygenation. Anesthesia may also influence the DA neurotransmitter system in the brain which plays a role in emotions, rewards, learning and memory functions. Specifically, anesthesia may participate in the pathogenesis of PND by affecting the DA system within the hippocampus. Future studies should explore the molecular mechanisms of these effects through techniques such as neuroimaging to study real-time effects to improve animal models to better simulate clinical observations. For clinical application, it is recommended that physicians exercise caution when selecting and managing anesthetic drugs by adopting comprehensive cognitive assessment methods to reduce post-anesthesia cognitive risk. Overall, this review provides a better understanding of the relationship between the hippocampal DA system and perioperative neurocognitive function and provides valuable guidance for prevention and treatment strategies for PND.https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302038perioperative neurocognitive disordershippocampusdopamineanesthesiasevofluraneisoflurane |
| spellingShingle | Feng-Nian Jia An-Ran Chen Hui-Hua Li Cui-Cui Yu Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders Journal of Integrative Neuroscience perioperative neurocognitive disorders hippocampus dopamine anesthesia sevoflurane isoflurane |
| title | Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders |
| title_full | Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders |
| title_fullStr | Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders |
| title_full_unstemmed | Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders |
| title_short | Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders |
| title_sort | research progress of hippocampal dopamine system changes in perioperative neurocognitive disorders |
| topic | perioperative neurocognitive disorders hippocampus dopamine anesthesia sevoflurane isoflurane |
| url | https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302038 |
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