Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context
Summary: Background: In recent years, a growing number of patients with multiple primary lung cancer (MPLC) are being diagnosed, and a subset of these patients is found to have a large number of lesions at the time of diagnosis, which are referred to as ‘super MPLC’. Methods: Here, we perform whole...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396424000549 |
| _version_ | 1797305257037922304 |
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| author | Zhenlin Yang Bolun Zhou Wei Guo Yue Peng He Tian Jiachen Xu Shuaibo Wang Xiaowei Chen Bin Hu Chengming Liu Zhijie Wang Chunxiang Li Shugeng Gao Jie He |
| author_facet | Zhenlin Yang Bolun Zhou Wei Guo Yue Peng He Tian Jiachen Xu Shuaibo Wang Xiaowei Chen Bin Hu Chengming Liu Zhijie Wang Chunxiang Li Shugeng Gao Jie He |
| author_sort | Zhenlin Yang |
| collection | DOAJ |
| description | Summary: Background: In recent years, a growing number of patients with multiple primary lung cancer (MPLC) are being diagnosed, and a subset of these patients is found to have a large number of lesions at the time of diagnosis, which are referred to as ‘super MPLC’. Methods: Here, we perform whole exome sequencing (WES) and immunohistochemistry (IHC) analysis of PD-L1 and CD8 on 212 tumor samples from 42 patients with super MPLC. Findings: We report the genomic alteration landscape of super MPLC. EGFR, RBM10 and TP53 mutation and TERT amplification are important molecular events in the evolution of super MPLC. We propose the conception of early intrapulmonary metastasis, which exhibits different clinical features from conventional metastasis. The IHC analyses of PD-L1 and CD8 reveal a less inflamed microenvironment of super MPLC than that of traditional non-small cell lung cancer (NSCLC). We identify the potentially susceptible germline mutations for super MPLC. Interpretation: Our study depicts the genomic characteristics and immune landscape, providing insights into the pathogenesis and possible therapeutic guidance of super MPLC. Funding: A full list of funding bodies that supported this study can be found in the Acknowledgements section. |
| first_indexed | 2024-03-08T00:23:19Z |
| format | Article |
| id | doaj.art-d7127329658f4ca6a9f4c0fae75ce7aa |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-03-08T00:23:19Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-d7127329658f4ca6a9f4c0fae75ce7aa2024-02-16T04:29:16ZengElsevierEBioMedicine2352-39642024-03-01101105019Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in contextZhenlin Yang0Bolun Zhou1Wei Guo2Yue Peng3He Tian4Jiachen Xu5Shuaibo Wang6Xiaowei Chen7Bin Hu8Chengming Liu9Zhijie Wang10Chunxiang Li11Shugeng Gao12Jie He13Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China; Guangdong Provincial People's Hospital/Guangdong Provincial Academy of Medical Sciences, Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer, Guangdong, 519041, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China; Corresponding author.Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China; Corresponding author.Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China; Corresponding author.Summary: Background: In recent years, a growing number of patients with multiple primary lung cancer (MPLC) are being diagnosed, and a subset of these patients is found to have a large number of lesions at the time of diagnosis, which are referred to as ‘super MPLC’. Methods: Here, we perform whole exome sequencing (WES) and immunohistochemistry (IHC) analysis of PD-L1 and CD8 on 212 tumor samples from 42 patients with super MPLC. Findings: We report the genomic alteration landscape of super MPLC. EGFR, RBM10 and TP53 mutation and TERT amplification are important molecular events in the evolution of super MPLC. We propose the conception of early intrapulmonary metastasis, which exhibits different clinical features from conventional metastasis. The IHC analyses of PD-L1 and CD8 reveal a less inflamed microenvironment of super MPLC than that of traditional non-small cell lung cancer (NSCLC). We identify the potentially susceptible germline mutations for super MPLC. Interpretation: Our study depicts the genomic characteristics and immune landscape, providing insights into the pathogenesis and possible therapeutic guidance of super MPLC. Funding: A full list of funding bodies that supported this study can be found in the Acknowledgements section.http://www.sciencedirect.com/science/article/pii/S2352396424000549Super multiple primary lung cancerGenomic characteristicsImmune landscapeWhole exome sequencingEarly intrapulmonary metastasis |
| spellingShingle | Zhenlin Yang Bolun Zhou Wei Guo Yue Peng He Tian Jiachen Xu Shuaibo Wang Xiaowei Chen Bin Hu Chengming Liu Zhijie Wang Chunxiang Li Shugeng Gao Jie He Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context EBioMedicine Super multiple primary lung cancer Genomic characteristics Immune landscape Whole exome sequencing Early intrapulmonary metastasis |
| title | Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context |
| title_full | Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context |
| title_fullStr | Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context |
| title_full_unstemmed | Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context |
| title_short | Genomic characteristics and immune landscape of super multiple primary lung cancerResearch in context |
| title_sort | genomic characteristics and immune landscape of super multiple primary lung cancerresearch in context |
| topic | Super multiple primary lung cancer Genomic characteristics Immune landscape Whole exome sequencing Early intrapulmonary metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S2352396424000549 |
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